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Diss Factsheets
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EC number: 442-600-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
HiTEC 7134 was tested for its mutagenic potential in bacterial cells of Salmonella and Escherichia, with and without metabolic activation. Two separate bacterial gene reverse mutation assays (Ames test) were conducted. One of the studies was used as a key study, while the other as a supporting study.Both satisfy the requirements of OECD Guideline 471. In the key study, HiTEC 7134 did not exert a mutagenic effect to any of the tester strains in the presence or absence of metabolic activation. The cytotoxicity of HiTEC 7134 was not evaluated, but the compound did precipitate at concentrations of 2500 µg/plate and above. Consequently, on the basis of this result H7134 may be deemed as non-mutagenic on bacterial cells under the particular conditions.
This is further supported by the second Ames test, where H7134 tested negative, using both liquid pre-incubation and plate incorporation treatments, in the presence and absence of metabolic activation. A significant increase was seen in the initial test with TA1535 at a dose of 5 µg/plate without S9 and in E. coli WP2 uvrA at several tested concentrations with S9. However, these results were not dose dependant nor were they reproducible in a second test. In addition, all revertant frequencies in all tests were within the historical control range. The compound was cytotoxic at concentration of 500 µg/plate and above.
HiTEC 7134 was evaluated for its clastogenic potential in an in vitro cytogenetic assay using human lymphocytes in two separate experiments in the presence and absence of metabolic activation. The study was performed in accordance with the OECD Guideline 473. No statistically significant increases in the percentage of aberrant cells, compared to the solvent control values, were recorded in cultures from either experiment treated in either the presence or absence of S9-mix, but the compound was cytotoxic at concentrations of 75 µg/ml and above. Therefore, it was concluded that H7134 does not induce chromosomal aberrations to human lymphocytes when tested under the specific conditions.
Short description of key information:
The mutagenic potential of HiTEC 7134 was assessed in three in vitro studies: 2 Ames tests and 1 cytogenetic assay on human lymphocytes. The test material may be considered as non-mutagenic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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