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EC number: 442-600-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02.01.2001 to 17.01.2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well-documented, GLP study, performed in accordance with the OECD Guideline 402 (1987; Acute dermal toxicity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 442-600-9
- EC Name:
- -
- Molecular formula:
- The substance is a UVCB for which it is not possible to provide a molecular formula
- IUPAC Name:
- (9E)-N-[(N'-hexadecanoyloctadecanehydrazido)methanimidoyl]octadec-9-enamide
- Details on test material:
- Description: Complex reaction product of an aminate base-carbonate and fatty acids
Chemical name: HiTEC 7134 Performance additive
- Physical state: viscous liquid
- Storage condition of test material: ambient temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk: APfSD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
This particular strain of rat was used due to the substantial background data available in the Laboratory which performed the study.
- Source: Rodent Breeding Unit, Alderley Park, Macclesfield, Cheshire, UK
- Age at study initiation: 8-12 w
- Weight at study initiation: males 286-391 g, females 211-237 g
- Housing: individually in cages
- Diet: ad libitum, RM1, supplied by Special Diet Services Limited, Witham, Essex, UK
- Water: ad libitum
- Acclimation period: at least 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 7X7 cm
- % coverage: 100
- Type of wrap if used: foil backed gauze patch held by a cohesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with clean swabs of absorbent cotton wool soaked in clean warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml/kg bw
VEHICLE
- Amount(s) applied (volume or weight with unit): no vehicle used - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw; selcted based on the results of the preliminary phase study, which is not reported.
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the rats were observed twice following application on day 1 for gross abnormalities, and once every day up to day 15 for systemic toxicity and skin irritation. Weights were recorded immediately before the dose application (day 1) and on days 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathology of all thoracic and abdominal viscera - Statistics:
- Not used
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died during the experiment.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- No signs of toxicity were detected.
- Other findings:
- Signs of slight skin irritation were seen in all animals, but they were completely reverrsible till the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- H7134 did not exert any acute toxicity after its dermal application on the skin of rats. The LD50 is higher than 2000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study, five male and five female Alpk: APfSD rats were dermally exposed to 2000 mg/kg bw of H7134 for 24h. The body surface exposed was 7X7 cm and it was initially clipped free of hair. Animals were then observed daily for 14 days, and their body weights were recorded at several intervals. No mortality occurred during the conduction of the experiment. Based on these results the dermal LD50males, females is considered to be > 2000 mg/kg bw. No treatment related clinical signs, necropsy findings or changes in body weights were detected. Slight skin irritation was detected in all animals, which totally resoved by the termination of the study. The study was performed in acordance with the OECD Guideline 402.
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