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EC number: 204-527-9 | CAS number: 122-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- KL2 due to RA
- Justification for type of information:
- Refer to the section 13 of IUCLID dataset for details on the read across justification. The algae study with the read across substance is considered sufficient to fulfil the information requirements as further explained in the provided endpoint summary.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on test solutions:
- Dilution water:
Source: Synthetic medium following NF EN ISO Norm 6341 from prepared from purified tap water (passed through activated charcoal and exchange resin and filtered at 0.22 µm)
Ca / Mg ratio: 4
Na / K ratio: 10
Oxygen content: « saturation »
Holding water different from dilution water: Yes, Elendt M7 supplemented with algae (specified as “Raphidocelis subcapitata”) - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Strain: 5 (A) CAL laboratory culture
Age: <24 h
Breeding method: Clone, adults separated from juveniles by sieving
Kind of food: Algae (specified as “Raphidocelis subcapitata”)
Feeding of animals during test: No - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- ca. 20°C
- Dissolved oxygen:
- saturation
- Salinity:
- Ca / Mg ratio: 4
Na / K ratio: 10 - Nominal and measured concentrations:
- Nominal: 0, 0,0095, 0,015, 0,024, 0,039, 0,063 and 0.01 mg/L
- Details on test conditions:
- - Daphnids were exposed in a static test to 0, 0,0095, 0,015, 0,024, 0,039, 0,063 and 0.01 mg/L test substance, using 2 times 10 dahnids per concentration. - Analytical control at the end of the exposure demontrated that concentration levels remained constant during the exposure time of the study. However, concentrations measured differed from 62% at 0.015 mg/L, increasing with the increase of concentration to 97 and 96% for 0.063 and 0.1mg/L. Concentrations for the lower levels could not be analysed, as they were below the analytical detection limit of 7.3 µg/L. All concentrations given relate to the test substance as tested.
- The concentration-response relationship appears to be typical for this type of substance. The study can be considered as valid despite a few missing details (e.g. detail of volume of solution used, some information on the dilution water). - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.016 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.005 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results of the read across study, the 48 h EC50 and NOEC values of the test substance are considered to be at 0.016 mg a.i./L and 0.0048 mg a.i./L (nominal) respectively.
- Executive summary:
A study was conducted to determine the short-term toxicity to aquatic invertebrates of the read across substance, C12-16 ADBAC (active: 50.58%), according to EU Method C.2, in compliance with GLP. Daphnia magna were exposed in a static test to nominal concentrations of 0, 0.0095, 0.015, 0.024, 0.039, 0.063 and 0.1 mg/L test substance, using 20 daphnids per concentration. Mobility was monitored throughout the experiment. Analytical dose verification was performed. Analytical control at the end of the exposure demonstrated that concentrations remained constant throughout the exposure period. However, measured concentrations differed by 62% at 0.015 mg/L, increasing to 97 and 96% at 0.063 and 0.1 mg/L. Concentrations for the lower levels could not be analysed as they were below the detection limit of 7.3 µg/L. Under the conditions of the study, the 48 h EC50 and NOEC were determined to be at 0.016 mg a.i./L and 0.0048 mg a.i./L (nominal) respectively (Thiebaud, 1999). Based on the results of the read across study, similar the 48 h EC50 and NOEC values can be considered for the test substance, C18 ADBAC, for short-term toxicity to aquatic invertebrates.
Reference
48h-EC50 = 0.032 mg/L - 95% confidence levels 0.019 - 0.051 mg/L as nominal concentration.
Based on active substance:
48h-NOEC = 0.0048 mg a.i./L
48h-LOEC = 0.0075 mg a.i./L
48h-EC50 = 0.016 mg a.i./L
48h-EC100= 0.05 mg a.i./L
Description of key information
Based on the results of the read across study, the 48 h EC50 and NOEC of the test substance, C18 ADBAC, for toxicity to Daphnia magna is considered to be 0.016 mg a.i./L and 0.0048 mg a.i./L (nominal) respectively.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.016 mg/L
Additional information
A study was conducted to determine the short-term toxicity to aquatic invertebrates of the read across substance, C12-16 ADBAC (active: 50.58%), according to EU Method C.2, in compliance with GLP. Daphnia magna were exposed in a static test to nominal concentrations of 0, 0.0095, 0.015, 0.024, 0.039, 0.063 and 0.1 mg/L test substance, using 20 daphnids per concentration. Mobility was monitored throughout the experiment. Analytical dose verification was performed. Analytical control at the end of the exposure demonstrated that concentrations remained constant throughout the exposure period. However, measured concentrations differed by 62% at 0.015 mg/L, increasing to 97 and 96% at 0.063 and 0.1 mg/L. Concentrations for the lower levels could not be analysed as they were below the detection limit of 7.3 µg/L. Under the conditions of the study, the 48 h EC50 and NOEC were determined to be at 0.016 mg a.i./L and 0.0048 mg a.i./L (nominal) respectively (Thiebaud, 1999). Based on the results of the read across study, similar the 48 h EC50 and NOEC values can be considered for the test substance, C18 ADBAC, for short-term toxicity to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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