Registration Dossier

Administrative data

First-aid measures

Emergency measure - Inhalation: Remove from exposure. If breathing ceases, give artificial
respiration. Get medical attention immediately.
Emergency measure - Eyes: Rinse opened eye for 15 minutes under running water or with
normal saline solution. Get medical attention immediately.
Emergency measure - Skin: If irritation occcurs seek medical attention.
Emergency measure - Ingestion: Do not induce vomiting. Seek medical attention immediately.

Fire-fighting measures

Recommended extinguishing agent: Water, dry chemical or CO2.

Product arising from burning: Under normal conditions of use, this material does not
present a significant fire or explosion hazard.

Product determined by test: N

Protective equipment: Full protective clothing and self-contained breathing
apparatus must be worn.


Fight the fire from a safe distance or protected location.

Accidental release measures

Emergency measures in case of spillage: Evacuate personnel from immediate vicinity.


Wear appropriate personal protective equipment conforming to
the relevant national or international standards, as
mentioned in section 2.3.10.


Avoid dust formation. Absorb spillages of solutions with a
suitable inert material (eg. sand or soil). Carefully
transfer the spillage to waste containers, or use a sealed

industrial vacuum machine. Containers filled with waste
material must be labelled in the same way as the original
substance containers.


Clean the spillage area by dissolving in solvent if
necessary. Do not discharge to drain.


Dispose of waste material in accordance with local
regulations and/or according to Schering Plough Good
Environmental Practice (GEP). Incineration is the preferred
disposal method.

Handling and storage

Handling: The substance should be stored, handled and used under
conditions of good industrial hygiene and in conformity with
any local regulations in order to avoid exposure.


Engineering controls are necessary to reduce exposure to the
substance.


When exposure cannot be prevented or adequately controlled
appropriate personal protective equipment should be worn.

Such protective equipment should conform to the appropriate
international or national standards as follows;

Chemical protective gloves to Standard EN374

Chemical protective clothing to Standard EN368

Eye protection to Standard EN166.

Furthermore, when respiratory protective equipment has to be
used, it must be capable of adequately controlling exposure,
be suitable for the purpose, and conform to the appropriate
international or national standards, such as a dust mask
conforming to EN149 FFP1.


These measures should be regarded as a minimum.

Storage: Store in a cool, dry, well ventilated area.


Keep containers tightly closed when not in use.

Packaging of the substance and or preparation: Double polythene lined fibreboard drums or plastic kegs or
Glass containers (Laboratory).

Transport information

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Marine transport (IMDG)

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Air transport ICAO/IATA

Remarks
Transport code: None
Transport: Avoid crushing the containers. In the event of a spillage,
observe the warning labels on the container.
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Exposure controls / personal protection

Stability and reactivity

Danger other than fire: Precautions against electrostatic discharge required. Avoid
high temperatures.

Chemical reaction with water: None which is hazardous.

Dust explosion: As with all organic powders there is a potential for dust
explosion when the substance becomes airborne.

The results of a dust explosivity test are as follows:

Kst 206Bar m/s

st class 2

MIE 10 - 25mg


There is considered to be a strong explosion hazard from the
material

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: There will be no discharge to the environment. Recovery from
minor spillages or accidental discharge is not economically
or technically feasible, and such waste material will be
disposed of by incineration or landfill. In principle, it
may be possible to recover larger spillages of
uncontaminated material for subsequent use.

Industry - Possibility of neutralisation: The notification tests have shown that the substance is
harmful by acute oral exposure, toxic by repeat oral
exposure and dangerous to the environment.

No chemical treatment is practicable to neutralise these
hazardous properties.

Industry - Possibility of destruction: controlled discharge: Contaminated containers or spillages of solutions mixed with
inert material (eg. sand, soil or proprietary adsorbent)
should not normally be disposed of by landfill.

Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning
under controlled conditions at a licensed waste treatment
processor in accordance with local regulations. Stack gases
should be scrubbed, because noxious fumes (eg. carbon oxides
and fluorine derivatives) could be formed.

Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to
the sewage system or the aqueous environment. However,
adverse effects on sewage treatment systems would be
unlikely.

Industry - Possibility of destruction - other: None.

Public at large - Possibility of recovery/recycling: Not applicable.

Public at large - Possibility of neutralisation: Not applicable.

Public at large - Possibility of destruction: controlled discharge: Not applicable

Public at large - Possibility of destruction - incineration: Not applicable.

Public at large - Possibility of destruction - water purification: Not applicable.

Public at large - Possibility of destruction - others: Not applicable.