Registration Dossier
Registration Dossier
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EC number: 438-670-5 | CAS number: 87199-17-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- May, 2017. Because of in the NDA 01-04-1385-00 carried out by Germany was not requested to indicate the endpoint study record, considering the data inserted in the course of the assessment to be correct and exhaustive the proper “Adequacy of study” has been selected.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.3
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 438-670-5
- EC Name:
- -
- Cas Number:
- 87199-17-5
- Molecular formula:
- Hill formula: C7H7BO3 CAS formula: C7H7BO3
- IUPAC Name:
- (4-formylphenyl)boronic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Wasser "ENGLISH" water
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Während der gesamten Studie ist kein Tier gestorben. Außer bei 2 Tieren (1 männl., 1 weibl.), bei denen ein leichter Gewichtsverlust festgestellt wurde, wurden keine weiteren systemischen Veränderungen registr
- Gross pathology:
- Effects on organs:
Bei der Sektion der am Ende der Studie getöteten Tiere
wurden keine makroskopisch sichtbaren Effekte festgestellt.
"ENGLISH"
The animals killed at the end of the observation period
showed no macroscopically visible changes. - Other findings:
- Signs of toxicity (local):
Rötliche Ausfluss aus der Nase am Tag der Applikation.
"ENGLISH"
Clinical signs were limited to red discharge from the nose
on the day dosing (day 1) only.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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