Registration Dossier
Registration Dossier
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EC number: 453-850-3 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.1tris (Akute-toxische-Klassen-Methode)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: rat, Wistar Hsd Cpb:WU (SPF)
Administration / exposure
- Vehicle:
- other: Polyethylenglykol 400 "ENGLISH" Polyethylene glycol 400
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2 - Clinical signs:
- other: Signs of toxicity related to dose levels: Bei einer Dosierung von 2000 mg/kg KGW an weiblichen Tieren wurde beobachtet: Auszehrung (vom 7. bis zum 9. Tag); schlechter Allgemeinzustand (7.Tag); verminderte Beweglichkeit (7. Tag). Bei einer Dosier
- Gross pathology:
- Effects on organs:
Ein weibliches Tier, das während der Studie starb, hatte
eine dunkel verfärbte Leber und Niere, einen schwarz
verfärbten Darm, eine leicht rosa verfärbte Lunge und war
abgemagert.
Das andere weibliche, während der Studie verstorbene Tier,
konnte wegen Kannibalismus nicht untersucht werden.
Der pathologische Befund an den nach Studienende getöteten
Tieren war nicht auffällig.
"ENGLISH"
A female animal which died during the study had a dark
discolored liver and kidney, a dark discolored intestine, a
slightly pink discolored lung and was emaciated.
The other animal that died during the study could not be
examined due to cannibalism.
The pathological findings relating to the animals killed at
the end of the study did not reveal any anomalies.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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