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EC number: 457-890-2 | CAS number: 860399-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013_09_18 to 2013_11_22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented study according to OECD guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- FC-131
- IUPAC Name:
- FC-131
- Reference substance name:
- -
- EC Number:
- 457-890-2
- EC Name:
- -
- Cas Number:
- 860399-11-7
- Molecular formula:
- C27H39N3O3
- IUPAC Name:
- (2E,5Z)-3-cyclohexyl-2-(cyclohexylimino)-5-{[4-(diethylamino)-2-methoxyphenyl]methylidene}-1,3-oxazolidin-4-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): FC-131
- Substance type: yellow powder
- Physical state: solid
- Analytical purity: 99. 8 % (HPLC)
- Impurities (identity and concentrations): 0.1 %, 4-diethylamino-2-methoxy-benzaldehyde
- Purity test date: 2013_07_03 (certificate of analysis)
- Lot/batch No.: 30610045
- Expiration date of the lot/batch: 2015_06_12
- Storage condition of test material: room temperature (20±5 °C)
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, adapted
- Details on inoculum:
- - Source of inoculum: sampled at 2013_09_19 from secondary effluent of the biologic sewage treatment plant Borsdorf district Panitzsch (Saxony, Germany)
- Preparation of inoculum for exposure: pre-condition by aerating for 4 days at test temperature, stopped one hour before starting the test to settle coarse particles down; supernatant used as inoculum
- Concentration: 1 mL/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2 mg/L
- Based on:
- ThOD/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- in the range: 0 to 28 days
- Details on study design:
- TEST CONDITIONS
- Medium:analytical grade reagents for mineral medium
- Carrier for test substance: quartz powder, inclusion of carrier control
- Test temperature: 20.5 ± 0.5 °C
- pH adjusted:yes to 7.4 ± 0.1 (in stock solution)
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: glass bottles with glas stoppers, 250 mL
- Number of culture flasks/concentration/condition: 3
- Method used to create aerobic conditions:aeration of sewage (inoculum) before test
- Measuring equipment: Oximeter with an O2-electrode and pH-meter with pH-electrode (Labmeter Hach HQ440d multi)
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Carrier blank: Yes
- Toxicity control: Yes
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
- Test performance:
- The highest degree of degradation observed was 4.7 % (without considering nitrification).
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2.4
- Sampling time:
- 4 d
- Remarks on result:
- other: this values are without nitrification
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2.9
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 4.7
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 3.5
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0.8
- Sampling time:
- 28 d
- Details on results:
- The results of the calculated pecentage degradation with complete nitrification are comparable with the results in the table above (without nitrification). The toxicity control indicated no toxicity of the test item towards the inoculum.
BOD5 / COD results
- Results with reference substance:
- For the reference substance sodium acetate 81.7 % degradation was observed on day 14.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- As degradation was much below 60 %, the test item FC-131 is considered as not ready biodegradable .
- Executive summary:
The areobic degradation potential of the test item FC-131 was investigated using the Closed Bottle test according to the OECD guideline No 301 D and GLP. The used inoculum was sampled in a biologic sewage treatment plant. The test was performed for 28 days. The maximum degradation rate observed was 4.7 %. Hence, FC-131 is considered as not ready biodegradable. The study is considered valid and reliable.
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