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EC number: 700-172-3 | CAS number: 634-55-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP , Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- ethyl 2-cyano-3-oxobutanoate
- EC Number:
- 700-172-3
- Cas Number:
- 634-55-9
- Molecular formula:
- C7 H9 NO3
- IUPAC Name:
- ethyl 2-cyano-3-oxobutanoate
- Details on test material:
- Test onditions : 21-22°C darkness
pH : 6.7-7.7
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 1.5 g/L
- Based on:
- test mat.
Results and discussion
% Degradationopen allclose all
- Parameter:
- other: ThOD NO3
- Value:
- ca. 3
- Sampling time:
- 9 d
- Parameter:
- other: ThODNO3
- Value:
- ca. 9
- Sampling time:
- 10 d
- Parameter:
- other: ThODNO3
- Value:
- ca. 35
- Sampling time:
- 11 d
- Parameter:
- other: THODNO3
- Value:
- ca. 70
- Sampling time:
- 21 d
- Parameter:
- other: ThODNO3
- Value:
- ca. 72
- Sampling time:
- 28 d
- Details on results:
- The mean biodegradation of Ethyl-2-cyano-3-oxobutanoate after 28 days of incubation was 73% (ThODNO3); the crite-rion of the 10 day window was passed on day 11.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The degradation rate of Ethyl-2-cyano-3-oxobutanoate under consideration of nitrification reached 60% within the 10-day window and after 28 days of incubation. According to the guideline OECD 301, Ethyl-2-cyano-3-oxobutanoate is con-sidered to be readily biodegradable.
- Executive summary:
The test flasks prepared were incubated at 22±. The pressure decrease in the reaction vessels was measured over complete experimental phase of 28 days using the BSB Sensomat system, Aqualytic Dortmund. The test flasks were closed gas-tight by a measuring head. Potassium hydroxide solution (45%) was used for trapping the produced carbon dioxide. The amount of O2consumed by the activated sludge was calculated from the decrease of pressure in the reaction vessel.
The incubate temperature was 21 -22°C.
The pH was 7.4 -7.6 at the start of the test and pH 6.7 -7.7 at the end of the test.
The oxygen demand of the inoculum control (medium and inoculum) was 25 mg O2/L and thus not greater than 60 mg O2/L within 28 days as required by the test guideline.
The reference item sodium benzoate was sufficiently degraded to 75% after 14 days and to 78% after 28 days of incubation.
In the toxicity control containing both the test item and reference 56% biodegradation was noted within 14 days and 79% biodegradation was determined after 28 days of incubation based on ThOD NH4.
According to the test guidelines the test item can be assumed to be not inhibitory on theaerobic activatedsludge micro organisms because degradation was >25% within 14 days.
The degradation rate of Ethyl-2-cyano-3-oxobutanoate under consideration of nitrification reached 60% within the 10-day window and after 28 days of incubation. According to the guideline OECD 301, Ethyl-2-cyano-3-oxobutanoate is considered to be readily biodegradable.
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