Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restrictions because it is an acceptable and reliable study carried out by OECD ToolBox v.3.2.0. Meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
other: software
Title:
QSAR ToolBox 3.2.0.103
Author:
OECD
Year:
2014
Bibliographic source:
http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:
Read-across from category members
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test organisms

Test organisms (species):
Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)

Study design

Test type:
static

Results and discussion

Effect concentrations
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
2.23 mg/L
Remarks on result:
other: Calculated by OECD Toolbox v.3.2

Any other information on results incl. tables

The category selection has been made by similarity basis with a 50% threshold by Dice protocol (Atom centered fragmments) to select only a homogeneous set of compounds with the steroidal core.

The cyclopentane perhydrophenanthrene scaffold, key scaffold of all steroids, is present in all the analogues that were taken into account to make the assessment.

Moreover, most features such as functional groups are in common between the compounds that allow to use these compounds as a homologous series suitable for this assessment.

An in deep analysis had been carried out to verify that the calculation fallen in the applicability domain and the steroidal derivatives selected by the OECD ToolBox were appropriate for the assessment.

The prediction is based on 2 values within the range 4.91 - 5.61, log(1/mol/L)

Prediction confidence = ± 4.49, log(1/mol/L) (95.0%)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
An EC50 of 2.23 mg/L has been predicted.