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EC number: 217-285-4 | CAS number: 1798-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
rat oral: LD50 between 1470 and 2150 mg/kg bw (comparable to OECD 401 with restrictions, BASF AG 80/204, 1981)
rat, inhalation: LC50 > 0.25 mg/L air/ 7hrs (BASF Inhalation Hazard Test, comparable to Annex V of OECD 403, BASF AG 80/204, 1981)
rat, dermal: no data available
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
The acute oral toxicity of (-)-Phenylacetylcarbinol was tested by single oral gavage to rats of both sexes, according to a BASF test method, which in principle was similar to OECD TG 401. Five animals per sex and group were used. The test doses were 1000, 1470, 2150, 3160 and 4640 mg/kg bw.
Whereas all animals of the lowest dose level survived, mortality was 40% (2/5 females, 0/5 males) at 1470 mg/kg bw, 80% (4/5 females, 4/5 males) at 2150 mg/kg bw, and 100% at 3160 and 4630 mg/kg bw, respectively. All animals suffered from clinical symptoms of toxicity including e.g., dypnoea, apathy, abnormal position, staggering, atony, unusual pain reflex, unusual corneal reaction, narcotic state, ruffled fur, erythema, exsiccosis and bad general state. Slightly decreased body weight gain was seen in surviving male animals of the 2150 mg/kg bw group for the first 7 days, and in male animals of the 1470 mg/kg bw group for the first 4 days. Body weight gain in surviving females was as expected. Necropsy of the survivors revealed no abnormalities. Necropsy of those animals that died revealed acute dilatation of ante-chamber and acute congestive hyperaemia of the heart, and atonic liquid stomach content.
The LD50 for males was set at ca. 1943 mg/kg bw
The LD50 for females was set at ca. 1470 mg/kg bw
The LD50 for both sexes was set > 1470 – 1150 mg/kg bw
Acute inhalation toxicity:
(-)-Phenylacetylcarbinol was tested in an inhalation hazard test according to a BASF test method which in principle was similar to that described in Annex V of OECD TG 403.Two tests were performed, each with 3 male and 3 females rats. The mean test concentration was determined as 0.25 mg/L.
No mortalities were observed after 7 h. The animals were wiping their mouths but none died. Necropsy was inconspicuous.
The LC50 was > 0.25 mg/L.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available oral toxicity study is considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is considered to be classified R22 for acute oral toxicity.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is considered to be classified in Category 4 for acute oral toxicity.
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