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EC number: 700-680-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The test substance Isostearic acid, esters with methyl α-D-glucoside is an organic compound, which is characterized as a viscous, slightly yellow liquid. The melting point of the test substance was not observed in the temperature range from -90 °C to 360 °C when tested according to OECD Guideline 102 (Melting point / ) and EU Method A.1 (Melting / Freezing Temperature). According to OECD Guideline 103 (Boiling point/boiling range) and EU Method A.2 (Boiling Temperature) a boiling point was also not observed below 360°C (633.15 K). Based on observations during the test it is supposed that in the temperature region between 75 and 175°C a small fraction of the test substance evaporated. After the experiment, a black coloured liquified residue remained in the sample container, which indicated that the test substance had reacted or decomposed. The density and relative density were determined to be 1 g/cm³ and 1 at 20 °C, respectively. According to REACH Regulation (Annex VII, 7.14, column II), the study on granulometry needs not to be done if the substance is marketed or used in a non solid or non granular form. Based on extrapolation at 20 °C the vapour pressure was calculated to be 1.47 x 10E-3. The vapour pressure was determined by comparison of its weight loss with the weight loss of a reference substance (hexachlorobenzene) at 100°C, 120°C, 130°C and 140°C. Since the weight loss of the test substance was lower then the weight loss of hexachlorobenzene at the same temperatures, it was concluded, that the test substance has a lower vapour pressure then hexachlorobenzene.
The n-octanol/water partition coefficients of the components of Isostearic acid, esters with methyl α-D-glucoside were investigated in a study conducted according to OECD Guideline 117 and EU Method A.8 (HPLC-Method). Since it was not possible to elute the test substance under isocratic conditions with a mobile phase of 75/25 (v/v) methanol/water, a gradient was applied directly after the isocratic run in order to rinse the test substance off the column. Due to the limited solubility of the test substance in aqueous mixtures the test solution (stock solution: 1456 mg/L) was used undiluted. The log Pow values were determined to be 0.3 for most likely methyl glucoside and > 6.5 for all other components.
The water solubility was determined according to OECD Guideline 105 (Water Solubility, 1995) and EU Method A.6 (Water Solubility, 2008). In general, two methods are available for the determination of the water solubility (flask method and column elution method). In a preliminary test, the water solubility of the test substance was 10E-2 g/L. Since it proved not possible to develop a sensitive analytical method for the determination of the low substance concentrations in samples from this test, performing a test based on the flask method in combination with visual interpretation was the only possible alternative. To support the visual results TOC analysis was performed after centrifugation for 5 min at 3500 g and 20°C. Visual interpretation of the test results was conducted by comparison: Test substance was stirred with distilled water at nominal concentrations of 0.5, 1.0 and 10 mg/l at 19.7 +/- 0.5°C for 72 hours. Since after this period all three test solutions revealed undissolved, the solubility of the test substance was determined to be 0.5 mg/l. The pH of the aqueous samples was 7.4 - 8.3. As the results of the TOC analysis were not unambiguous, indicating, that an excess of test substancewas not completely removed from the test solutions only the results from the visual interpretation were reported.
According to REACH Regulation (Annex VII,
7.6, column II), the study on surface tension needs not to be
performed if the water solubility is <1 mg/L at 20°C. It
was concluded that Isostearic
acid, esters with
methyl α-D-glucoside has
no flash point. A test was investigated according
to EU Method A.9 (Flash-Point, 2008), ISO 2719:2002 (Determination of
flash point - Pensky-Martens closed cup method, 2002), and ASTM D93
(Standard test methods for flash point by Pensky-Matens Closed CUP
Tester, 2002). No flash-point was observed up to a temperature of 286°C
(atmospheric pressure 101.3 - 102.1 kPa, attempt was made to ignite the
vapour of the test substance every 2°C, starting at 24°C). At the
temperature of 286°C the experiment was stopped due to severe smoke
generation. Smoke was observed from 176°C onwards. The
smoke was not ignitable.
The auto-ignition temperature of Isostearic
acid, esters with
methyl α-D-glucoside was
determined to be 415 °C at 1008.2-1032.5 hPa. According to
REACH Regulation (Annex XI, 1.), the study on flammability needs
not to be done if the available data are sufficient for assessment. For
liquids the relevant endpoint is the flash point. According to REACH
Regulation (Annex VII, 7.11, column II), the study on explosiveness needs
not to be done if the test substance does not contain chemical groups
indicating explosive properties. According to REACH Regulation (Annex
VII, 7.13, column II), testing of oxidising properties needs not
to be conducted as the test substance does not contain any structural
groups known to be correlated with a tendency to react exothermically
with combustible material. The
test substance dissolved in methanol was stable for at least 1
day at room temperature. A
pH of 7.4 was found at a test substance concentration of 0.5 mg/L
and a pH of 8.3 at a test substance concentration of 10 mg/L at 19.7°C
each. The pKa values of the test substance components were
estimated using the Perrin calculation method (pKaLc 5.0, module in
Pallas 3.0,
CompuDrug International). The calculation yielded pKa values ranging
from 13.1 to 17.9 for methyl glucoside and pKa values ranging from 12.9
to 16.5 for the monoester.
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