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EC number: 922-676-4 | CAS number: 286426-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-[(1S)-2-[benzyl(methyl)amino]-1-hydroxyethyl]phenol
- Cas Number:
- 286426-31-1
- Molecular formula:
- C17 H20 O2
- IUPAC Name:
- 3-[(1S)-2-[benzyl(methyl)amino]-1-hydroxyethyl]phenol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Physical state: solid
- Analytical purity: 99,7 %
- Storage condition of test material: room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-88353 Kißlegg
- Weight at study initiation: 3 kg, 3.6 kg, 2.8 kg
- Housing:Individually housed in ABS-plastic rabbit cages, floor 24 cm²
- Diet : Free access to Altromin 2123 maintenance diet rabbit, rich in crude fiber, totally-pathogen-free-TPF
- Water : Free access to tap water ( drinking water, municipalresidue control, microbiol. controlled periodically )
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15 -21
- Humidity (%): 45-65
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12:12 ,light 6:30 - 18:30
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Observation period (in vivo):
- 96 h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 286,285,297
- Time point:
- other: 1,24,48,72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: 286,285,297
- Time point:
- other: 1,24,48,72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 286,285,297
- Time point:
- other: 1,24,48, 72 h
- Score:
- 0 - 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96 h
- Irritation parameter:
- chemosis score
- Basis:
- animal: 286,285,296
- Time point:
- other: 1,24,48,72 h
- Score:
- 0 - 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritant / corrosive response data:
- see table 1/2/3
Any other information on results incl. tables
Tabel 1 Eye Irritation Scores
Animal No. | hour p.appl. | Cornea | Iris | Conjunctivae A | Conjunctivae B | Sub Totals | Cumul. Score | ||
T / C | T / C | T / C | T / C | Cn Ir Cj | |||||
286 female | 1 | nr | 0 /0 | 0 /0 | 1/0 | 1/0 | 0 0 2 | 2 | |
24 | nr | 0 /0 | 0 /0 | 1/0 | 0 /0 | 0 0 1 | 1 | ||
48 | nr | 0 /0 | 0 /0 | 1/0 | 0 /0 | 0 0 1 | 1 | ||
72 | nr | 0 /0 | 0 /0 | 0 /0 | 0 /0 | 0 0 0 | 0 | ||
285 female | 1 | nr | 0 /0 | 0 /0 | 1/0 | 1/0 | 0 0 2 | 2 | |
24 | nr | 0 /0 | 0 /0 | 1/0 | 0 /0 | 0 0 1 | 1 | ||
48 | nr | 0 /0 | 0 /0 | 1/0 | 0 /0 | 0 0 1 | 1 | ||
72 | nr | 0 /0 | 0 /0 | 0 /0 | 0 /0 | 0 0 0 | 0 | ||
596 female | 1 | nr | 0 /0 | 0 /0 | 1/0 | 1/0 | 0 0 2 | 2 | |
24 | nr | 0 /0 | 0 /0 | 1/0 | 1/0 | 0 0 2 | 2 | ||
48 | nr | 0 /0 | 0 /0 | 1/0 | 1/0 | 0 0 2 | 2 | ||
72 | nr | 0 /0 | 0 /0 | 1/0 | 0 /0 | 0 0 1 | 1 | ||
96 | nr | 0 /0 | 0 /0 | 0 /0 | 0 /0 | 0 0 0 | 0 |
T = Test , C = Control: A = Redness; B= Chemosis; nt = not rinsed;
marked figures = used for calculation
Table 2 Mean Cumul. Score - 24, 48 ,72 hour reading
Time | Cumul. Score | Mean Cumul. Score |
24 h | 4.00 | 1.33 |
48 h | 4.00 | 1.33 |
72 h | 1.00 | 0.33 |
Tabel 3 Individual and Total Mean Cumul. Score - 24 , 48, 72 hour reading
Animal | Sex | Cornra | Iris | Conjunctivae A | Conjunctivae B | Cumul. Score | Primary Irritation Score |
286 | f | 0.00 | 0.00 | 0.67 | 0.00 | 0.67 | |
285 | f | 0.00 | 0.00 | 0.67 | 0.00 | 0.67 | |
296 | f | 0.00 | 0.00 | 1.00 | 0.67 | 1.67 | |
Total Mean | 0.00 | 0.00 | 0.78 | 0.22 | 1 .0 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Considering the reported data of this irritation study it can be stated that the test item caused minimal irritation but no corrosiv effects to the eye of
albino rabbits.
According to Directive 93/21 EEC the labelling of the test item as an eye irritant is not required. - Executive summary:
In this eye irritation study the test item L-Benzyladrianol Base was applied to the lower conjunctival sac of one eye of 3 NZW-rabbits ( Cr:KBL(NZW) BR) at a dose of 0.1 g per application site. The untreated other eye served as control.
Observation were calculated and compared to the control eyes, 1h , 24 h, 48 h, 72 h and 96 hours after application of the test item.
The eyes were not rinsed after 24 hours.
The application of the test item L-Benzyladrianol Base at a dose of 0.1 g caused minimal blepharospasm in all animals immediately after the application.
1 hour after application a slight erythema and chemosis of the conjunctivae was visible in all animals.
Minimal signs of irritation were visible until the 48 h reading in all of the 3 test animals and in one of the three animals at the 72 h
reading. No chnages were visible at the 96 h reading in any of the 3 test animals.
No corneal lesion were found upon fluorescein examination.
The test item produced no corrosion or irreversible effects in any of the animals.
The total mean cumulative scores of the 24, 48 and 72 hour reading did not exceed the limit values according to
Directive 93/21 EEC in any case.
No other toxic effects were observed.
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