Registration Dossier

Toxicological information

Genetic toxicity: in vivo

Currently viewing:

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Annex V (Micronucleus)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: Mouse (Tif:Magf)

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
Arachis oil
No. of animals per sex per dose:
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours

Results and discussion

Test results
Sex:
not specified
Toxicity:
yes
Remarks:
(Doses producing toxicity: P/N ratio - no apparent effect)
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
None.