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EC number: 609-333-1 | CAS number: 37143-54-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: comparable to OECD-guideline 401.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 609-333-1
- EC Number:
- 609-333-1
- Cas Number:
- 37143-54-7
- Molecular formula:
- C4 H11 N O
- IUPAC Name:
- 609-333-1
- Details on test material:
- - Name of test material (as cited in study report): 1-methoxy-2-aminopropan
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, D-7950 Biberach, FRG
- Weight at study initiation: 180 - 200 g
- Fasting period before study: 16 h
- Housing: stainless steel wire mesh cages, Type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet (e.g. ad libitum): KLIBA-Labordiaet 343, Klingentalmühle, CH-4303 Kaiseraugst, Switzerland; ad libitum
- Water (e.g. ad libitum): tap water; ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 316; 681; and 1470 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighting: Recording of the signs and symptoms several times on the day of administration; at least once each work day. Check for moribund and dead animals twice each workday and once on holidays. Weighting of the animals before and on days 7 and 13 after the administration.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross-pathology - Statistics:
- According to Finney, D.J., Probit Analysis, cambridge University Press, 3RD ED., 1971
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 080 mg/kg bw
- Remarks on result:
- other: Value from interpolation
- Mortality:
- One female of the 681 mg/kg b.w. dose group was found dead on day 14 after application. 3 males and 5 females of the 1470 mg/kg b.w. dose group died within the first day after administration.
- Clinical signs:
- Clinical observation revealed dyspnea, apathy, abnormal position, staggering, atonia, paresis, piloerection, exsiccosis, salivation and poor general state in the 1470 mg/kg b.w. dose group in males and females. The two surviving males of this dose group recreated within 9 days after administration.
One female animal of the 681 mg/kg b.w. dose group showed dyspnea, apathy, piloerection and poor general state. These symptoms were only seen on days 8 and 9. - Body weight:
- The expected body weight gain was observed in the course of the study.
- Gross pathology:
- Animals that died (male and female) in general showed congestion, reddened mucosa and bloddy contents in stomach and intestine. One animal showed empty, intensified inflated intestines and emaciation.
No pathology findings were noted from sacrificed animals (male and female).
Any other information on results incl. tables
Under the conditions of this study the median lethal dose of 1-methoxy-2-aminopropane in both, male and female rats was calculated by interpolation to be 1080 mg/kg b.w..
Applicant's summary and conclusion
- Conclusions:
- According to the results of this study, the substance was classified R22 (EU) and Cat. 4 (GHS).
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