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Diss Factsheets
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EC number: 203-526-0 | CAS number: 107-85-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 01-01-1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication/study report which meets basic scientific principles. Read across of results obtained with other short-chain (C3-C8) from n/i-aliphatic amines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The respiratory irritation was examined in mice during the first 15 minutes of the inhalation exposure at several concentrations in the air with and without tracheal cannulation. The maximum respiratory depression was compared with the breathing rate before the inhalation exposure.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Pentylamine
- EC Number:
- 203-780-2
- EC Name:
- Pentylamine
- Cas Number:
- 110-58-7
- IUPAC Name:
- pentan-1-amine
- Reference substance name:
- n-Pentylamine
- IUPAC Name:
- n-Pentylamine
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- air
- Details on exposure:
- INHALATION
Method: head only
Exposure duration: 60 minutes
Inhalation concentration: 17-300 ppm, depending on test substance
Number of exposure concentrations: 4-6 per test substance
Number of animals: 6 previously unexposed mice at each level - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Sampling on silica gel, desorption and derivation to the m-toluol derivatives. Analyses: HPLC/UV detection on reverse phase column,
- Duration of treatment / exposure:
- 60 minutes
- Frequency of treatment:
- 1
Doses / concentrations
- Remarks:
- Doses / Concentrations:
n-pentylamin: 25, 50, 100, 200 ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 6
- Control animals:
- other: not required
Examinations
- Examinations:
- Breathing frequency 15 min before expsoure, and 15 min after start of exposure.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Primary aliphatic amines including n- and i-pentylamine cause respiratory irritation due to irritation of the upper airways
- Executive summary:
Primary aliphatic amines including n- andi-pentylamine cause respiratory irritation due to irritation of the upper airways. The RD50values of the examined saturated n- and iso-amines with chain lengths of C3 to C8 decrease with increasing chain length. A linear relationship was obtained in a plot of Log RD50versus Log P. The RD50of n-pentylamine was 64 ppm (Gagnaire et al. 1993).
The RD50values of n- andiso-amines were very similar. It is therefore concluded that the RD50value of isopentylamine is in the range of 60 -70 ppm.
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