Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: A scientific study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
- Principles of method if other than guideline:
- A study with 2 guinea pigswith 0.5, 2.0, 5.0, 10.0% substance. 24h of application. Readings at 1, 24, 48h.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Reference substance name:
- Mercaptobenzothiazole
- IUPAC Name:
- Mercaptobenzothiazole
- Details on test material:
- - Name of test material (as cited in study report):Mercaptobenzothiazole
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Details on test animals or test system and environmental conditions:
- 350-420 g, 5-6 weeks, from Charles River Breeding Laboratories, Inc. Massachusetts.
They were housed in individual cages and fed on a pellet diet.
The housing conditions were a room temperature set at 70+/-2ºF, a relative humidity of 45%, 10 air changes per hour, and a 12/12 hour light cycle.
Test system
- Amount / concentration applied:
- 0.5, 2,5, 10 % w/w
- Duration of treatment / exposure:
- 24h
- Observation period:
- 1, 24 and 48h after removal of the test material
- Number of animals:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Thereshold irritation concentration
- Basis:
- mean
- Reversibility:
- no data
- Remarks on result:
- other: 5% concentration resulted in at least a minimal amount of erythema.
Applicant's summary and conclusion
- Conclusions:
- 5% and 10% concentrations of the test material produced slight irritant reactions.
- Executive summary:
The aim of the study was to determine the irritant potential of the test material. Concentrations of the test material: 0.5, 2,5, 10 % w/w. The result was: 5% and 10% concentrations of the test material produced slight irritant reactions.
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