Registration Dossier
Registration Dossier
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EC number: 213-367-9 | CAS number: 939-97-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Proprietary study conducted in 1979, only a brief report containing the endpoint is available
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Draize method
- GLP compliance:
- no
Test material
- Reference substance name:
- p-tert-butylbenzaldehyde
- IUPAC Name:
- p-tert-butylbenzaldehyde
- Details on test material:
- The test material was p-tert-butylbenzaldehyde (code Giv 82-2601)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No further details available.
Test system
- Vehicle:
- other: propylene glycol
- Controls:
- not specified
- Amount / concentration applied:
- 0.5% prepared in propylene glycol
- Duration of treatment / exposure:
- No information available.
- Observation period (in vivo):
- No information available.
- Number of animals or in vitro replicates:
- No information available.
- Details on study design:
- No information available.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: irritation
- Remarks on result:
- other: no effects observed
- Irritant / corrosive response data:
- No eye irritation was observed following exposure to 0.5% test material in propylene glycol.
- Other effects:
- None reported.
Any other information on results incl. tables
No further information available.
Applicant's summary and conclusion
- Conclusions:
- A 0.5% concentration of p-tert-butylbenzaldehye in propylene glycol was not irritating to rabbit eyes.
- Executive summary:
A 0.5% concentration of p-tert-butylbenzaldehye in propylene glycol was not irritating to rabbit eyes.
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