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EC number: 696-145-8 | CAS number: 944730-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study experimental phase 2012-11-13 to 2013-01-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as reliable without restriction according to Klimisch et al (1997).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- tetrasodium 1,8,15,22-tetra-(3-sulfoxypropylsulfonyl)copper phthalocyanine
- EC Number:
- 696-145-8
- Cas Number:
- 944730-39-6
- Molecular formula:
- C44H36CuN8O20S8 .4Na
- IUPAC Name:
- tetrasodium 1,8,15,22-tetra-(3-sulfoxypropylsulfonyl)copper phthalocyanine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Analysis of the tests by HPLC was carried out initially and at 5 days.
For the initial HPLC analysis, the above remaining test solutions were left to reach room temperature and then 0.25 ml of each hydrolysis test was diluted to 100.0 ml with ELGA Ultrapure water.
For the 5 days hydrolysis analysis, one vial of each test was removed from the oven after 5 days and allowed to cool to room temperature. 0.25 ml of each test was diluted to 100.0 ml with ELGA Ultrapure water. - Buffers:
- Buffer blanks were also run to demonstrate specificity.
Preparation of Buffer Solutions
pH 4.0 Buffer Solution
164ml of 0.2M acetic acid solution was added to 36ml of 0.2M sodium acetate and diluted to 1 litre with ELGA Ultrapure water. The solution was degassed with helium.
pH 7.0 Buffer Solution
296ml of 0.1N sodium hydroxide solution was added to 500ml of 0.1M monopotassium phosphate solution and diluted to 1 litre with ELGA Ultrapure water. The solution was degassed with helium.
pH 9.0 Buffer Solution
213ml of 0.1N sodium hydroxide solution was added to 500ml of 0.1M boric acid in 0.1M potassium chloride and diluted to 1 litre with ELGA Ultrapure water. The solution was degassed with helium. - Details on test conditions:
- TEST SYSTEM
- Sterilisation method: All glassware used during the analysis was autoclaved before use. All buffers were autocalved at 121ºC for 15 min and then placed in a 50ºC oven to warm overnight.
- Measures to exclude oxygen: Buffer solutions were degassed with helium.
OTHER TEST CONDITIONS
- Adjustment of pH: The pH of each buffer solution was measured prior to use and no pH adjustment was required. The initial pH's of all test solutions were within 0.1 pH units of required pH, therefore no pH adjustment was necessary.
- Dissolved oxygen:
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 12 094 mg/L
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 13 260 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 13 251 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 12 864 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 12 763 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 13 412 mg/L
- Number of replicates:
- 2 per pH
Results and discussion
- Preliminary study:
- The results of the initial HPLC analysis show that at pH 4.0, 7.0 and 9.0 there had been less than 10% hydrolysis after 5 days at 50ºC ±0.5ºC versus the initial time point. Therefore no further work is required.
- Transformation products:
- not measured
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 99.9
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 100.2
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 100.2
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 99.9
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- 100.2
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
Dissipation DT50 of parent compound
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results of the initial HPLC analysis show that at pH 4.0, 7.0 and 9.0 there had been less than 10% hydrolysis after 5 days at 50ºC ±0.5ºC versus the initial time point. Therefore no further work is required.
- Executive summary:
Introduction
This study was undertaken to to assess hydrolysis of the test material as a function of pH. The method was designed to be compatible with OECD Guideline 111.
Results & Conclusions
The results of the initial HPLC analysis show that at pH 4.0, 7.0 and 9.0 there had been less than 10% hydrolysis after 5 days at 50ºC ±0.5ºC versus the initial time point. Therefore no further work was carried out.
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