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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Study period:
Jun-Jul 1989
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well reported GLP guideline study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990
Reference Type:
review article or handbook
Title:
Acute Toxicologic Evaluation of N-Formylaminosorbit
Author:
Bomhard E, Märtins E, Stropp G
Year:
1997
Bibliographic source:
International Journal of Toxicology 16, Suppl. 2, 65, 1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-deoxy-1-formamido-D-glucitol
EC Number:
618-251-5
Cas Number:
89182-60-5
Molecular formula:
C7 H15 N O6
IUPAC Name:
1-deoxy-1-formamido-D-glucitol
Details on test material:
N-Formylaminosorbit, solid, colourless-light yellow crystals, batch 1/89-1, content 98.1%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Remarks:
tap water
Doses:
2000 mg/kg with an administration volume of 20 ml/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

No deaths occurred as well as no deviations in weight development. 15 minutes to 2 hours after application piloerection was observed in all males, females showed no clinical signs.No gross pathological findings at sacrifice were observed.

Applicant's summary and conclusion

Executive summary:

The acute oral toxicity to male and female Wistar rats of N-Formylaminosorbit was assessed. The test compound was formulated in tap water, the administration volume was 20 ml/kg body weight. No deaths occurred as well as no deviations in weight development. 15 minutes to 2 hours after application ruffled fur was observed in all males, females showed no clinical signs.No gross pathological findings at sacrifice were observed.

Therefore, the LD50 of N-Formylaminosorbit in male and female rats is above 2000 mg/kg.