Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 700-934-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No carcinogenicity study on experimental animals is available for EUF. The compound is assumed to hydrolyse rapidly within the body. Effects for hydrolysis products in adequate dilutions are supposed.
As the database for formaldehyde is comprehensive, no test for carcinogenicity is required. Assuming that the discussed in-vitro mutagenic effects of EUF are based on formaldehyde, no tumour formation is expected at non-irritant concentrations. No carcinogenic effects were reported for ethylene glycol or urea respectively.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The final classification of formaldehyde is still in discussion in the national competent authorities and the European Commission.
Additional information
Data on experimental animals: Data on long-term drinking water studies in rats revealed neither systemic carcinogenic effects nor sufficient evidence for local carcinogenic effects in the gastrointestinal tract. However, repeated oral studies consistently show that exposure to drinking water dose levels >50 mg/kg/day can damage epithelial tissue of the gastrointestinal tract, especially at dose levels >100-200 mg/kg/day.
Data on this endpoint showed local irritation but no carcinogenic effects. However, in initiation/promotion experiments formaldehyde significantly reduced the latency time for the development of tumours.
The available data on dermal exposure revealed local irritation but no carcinogenic effects.
In summary, the weight of evidence that formaldehyde induces systemic or local carcinogenic effects after oral or dermal exposure is insufficient.
There is clear evidence from chronic inhalation studies in rats that formaldehyde causes tumours in the nasal cavity. Even after subchronic exposure periods nasal tumours were induced. Limited data are available in mice; no tumours were detected in hamsters.
Data on carcinogenicity in humans: Numerous epidemiological studies are available in humans occupationally exposed via inhalation. The data suggested an increased risk of cancer at two tumour sites: the upper respiratory tract and the haematopoietic system. Some evidence for an association between nasopharyngeal tumours and formaldehyde exposure was reported in former cohort studies. Some epidemiological evidence for an association between formaldehyde exposure and leukaemia has been reported. However, in contrast to nasopharyngeal tumours, no plausible mechanism for the induction of leukaemia in humans is found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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