Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 934-716-8 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD SIDS evaluation: Guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Dermal Toxicity Study in Rabbits
- Author:
- Rinehart, WE
- Year:
- 1 978
- Bibliographic source:
- Toxicological Resources Unit, Bio/dynamics Inc., 1978.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 16 CFR 1500.40
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- sodium carbonate monohydrate
- IUPAC Name:
- sodium carbonate monohydrate
- Details on test material:
- TS-Freetext:
SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.: Not reported.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Vehicle:
- water
- Doses:
- 2000 mg/kg bw as a 1000 mg/ml aqueous slurry.
- No. of animals per sex per dose:
- 6
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None
Any other information on results incl. tables
RS-Freetext:
MORTALITY: No deaths occurred during the experiment.
CLINICAL SIGNS: 3/6 animals gained weight during the 14 days
the experiment lasted. 3/6 animals lost weight or did not
gain weight. Well-defined to severe erythema and slight to
severe oedema were observed in all six animals at the
24-hour dermal observations. The severity of the lesions did
not vary significantly between the animals with abraded or
non-abraded skin. Lethargy and hypernea were observed in
each animal during the first 24 hrs following compound
administration.
NECROPSY FINDINGS: Not reported.
POTENTIAL TARGET ORGANS: Skin.
SEX-SPECIFIC DIFFERENCES: Not reported.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
