Registration Dossier
Registration Dossier
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EC number: 212-556-3 | CAS number: 826-55-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No reliable data are available
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No reliable data are available.
Effects on developmental toxicity
Description of key information
Data reliable are considered for classification.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study results are considered because the substance is in the Applicability Domain (AD) of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Guideline:
- other: REACH guidance on QSARs R6, May 2008
- Principles of method if other than guideline:
- General model for estimating the developmental toxicity.
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Conclusions:
- The study results are in the Applicability Domain (AD) of the models. Therefore, the substance is development toxicant.
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The VEGA QSAR shows that FEXO-1 could be development toxicant; but due to the weight of evidence caused by lack of validity of the model, FEXO-1 is considered inconclusive for classification.
Toxicity to reproduction: other studies
Additional information
The VEGA QSAR shows that FEXO-1 could be development toxicant; but due to the weight of evidence caused by lack of validity of the model, FEXO-1 is considered inconclusive for classification.
Justification for classification or non-classification
According to Directive 67/548/EEC and to Regulation (EC) n. 1272/2008, the substance should not be classified for development toxicity but it considered inconclusive.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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