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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 905-908-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-10-21 to 2012-11-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study according to OECD TG 431 (2004) and under GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of CXN1-55
- IUPAC Name:
- Reaction mass of CXN1-55
- Details on test material:
- - Name of test material (as cited in study report): Reaction mass of CXN1-55- Substance type: multi-constituent substance- Physical state: Paste- Stability under test conditions: substance considered stable under normal ambient conditions- Storage condition of test material: at room temperature at 20 ± 5 °C, in the dark.
Constituent 1
Test animals
- Species:
- other: EpiDerm™ tissues model
- Strain:
- other: EpiDerm™
- Details on test animals or test system and environmental conditions:
- EXPERIMENTAL DETAILS- Source: Epi-200 kits and MTT-100 assays were purchased from MatTek Corporation (Ashland, MA 01721, USA).- Age at study initiation: EpiDerm™ tissues were shipped at 4 °C on medium-supplemented agarose gels in a 24- well plate on October 23, 2012. After receipt of the EpiDermTM tissues before starting the assay, the tissues were transferred to 6-well plates with assay medium, which was immediately replaced before the test is started. Test start was October 24, 2012. At least 1 hour before dosing, EpiDerm™ tissues were removed from the refrigerator. Under sterile conditions using sterile forceps, the inserts were transferred into 6-well plates containing the pre-warmed assay medium. A 2 -well plate was prepared as holding plate containing 300 μL assay medium. The holding plate was pre warmed in an incubator (37 ± 1.5 °C, 5 ± 0.5 % CO2) until use.- Acclimation period: 1 dayENVIRONMENTAL CONDITIONS- Temperature (°C): 37 ± 1.5 °C- Humidity (%): not applicable for this in vitro test- Air changes (per hr): not applicable for this in vitro test- Photoperiod (hrs dark / hrs light): not applicable for this in vitro test- CO2 concentration (%): 5 ± 0.5 % CO2IN-LIFE DATES: 2012-10-24 to 2012-10-25
Test system
- Type of coverage:
- other: EpiDerm™ tissues model
- Preparation of test site:
- other: EpiDerm™ tissues model
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: EpiDerm™ tissues treated with water
- Amount / concentration applied:
- TEST MATERIAL- Amount(s) applied (volume or weight with unit): Each approximately 25 – 28 mg of the test item was applied to each tissue, wetted with 50 μL of deionised water, and spread evenly to the surface- Concentration: 25-28 mg/0.050 mL = 500-560 g/LVEHICLE- Amount(s) applied (volume or weight with unit): no vehicle
- Duration of treatment / exposure:
- 3 minutes and 1 hour
- Observation period:
- after exposure period 3 hour inmcubation period in MTT-solution (MTT=(3-4,5-dimethyl thiazol 2-yl) 2,5-diphenyl-tetrazolium bromide) rinsing with DBPS (Dulbecco's Phosphate Buffered Saline) immersing within isopropanole transfering to blue formazan solution
- Number of animals:
- Duplicates of EpiDerm™ tissues were exposed to the test item, positive or negative control for each of two different exposure periods: 3 minutes and 1 hour.
- Details on study design:
- TEST SITE- Area of exposure: EpiDerm™ tissues- % coverage: 100 %REMOVAL OF TEST SUBSTANCE- Washing (if done): yes- Time after start of exposure: 3 minutes or 1 hourSCORING SYSTEM: determination of optical density
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corrosion of EpiDerm™ tissues models
- Basis:
- other: relative absorbance value
- Time point:
- other: exposure of 3 minutes
- Score:
- > 50
- Reversibility:
- other: viability
- Irritation parameter:
- other: corrosion of EpiDerm™ tissues models
- Basis:
- other: relative absorbance value
- Time point:
- other: exposure of 1 hour
- Score:
- > 15
- Reversibility:
- other: viability
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationnon corrosiveCriteria used for interpretation of results: other: EU CLP and UN GHS
- Conclusions:
- In this valid, reliable and conclusive study according to OECD TG 431 and under the reported experimental conditions, the test item Reaction mass of CXN1-55 was non corrosive to skin according to EU CLP and UN GHS.
- Executive summary:
This valid, reliable and conclusive in vitro study was performed to assess the corrosive potential of Reaction mass of CXN1-55 by means of the Human Skin Model Test with EpiDerm™ tissues models according to OECD TG 431.
Independent duplicate tissues of EpiDermTM were exposed to either the test item Reaction mass of CXN1-55 (each approximately 25 – 28 mg, each wetted with 50 μL of deionised water, and spread evenly to the surface), the negative control (deionised water) or the positive control (8.0 N KOH) for 3 minutes and 1 hour, respectively.
After exposure to the negative control the absorbance values met the required acceptability criterion of mean OD570 ≥ 0.8 for both treatment intervals thereby confirming the acceptable quality of the tissues.
Exposure to the positive control induced a decrease in the relative absorbance compared to the negative control, both for the 3 minutes exposure period (22.9 %) and for the 1 hour exposure period (9.4 %) thus confirming the validity of the test system and the specific batch of tissue models.
After exposure to the test item Reaction mass of CXN1-55 the relative absorbance value did not decrease at all after 3 minutes exposure (104.9 %). After 1 hour exposure the relative absorbance value was reduced to 87.3 %. Both values did not exceed the threshold for corrosivity which is defined to be 50 % after the 3 minutes exposure and 15 % after the 1 hour exposure. Therefore, the test item was not considered to be corrosive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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