Registration Dossier
Registration Dossier
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EC number: 800-765-8 | CAS number: 1424149-03-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Critical Review of Hydrolysis of Organic Compounds in Water Under Environmental Conditions.
- Author:
- Mabey, W. and Mill, T.
- Year:
- 1 978
- Bibliographic source:
- J. Phys. Chem. Ref. Data 1978, 7(2): 383-415
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-methylacetamide
- EC Number:
- 201-182-6
- EC Name:
- N-methylacetamide
- Cas Number:
- 79-16-3
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N-methylacetamide
Constituent 1
Results and discussion
- Transformation products:
- no
Dissipation DT50 of parent compound
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- ca. 38 000 yr
Applicant's summary and conclusion
- Conclusions:
- N-Methyl acetamide, CAS No. 79-16-3 has a half-life of 38000 years (pH7, 25 deg C, Reference: Mabey, W. and Mill, T. 1978. Critical Review of Hydrolysis of Organic Compounds in Water Under Environmental Conditions. J. Phys. Chem. Ref. Data 1978, 7(2): 383-415). The registration substance contains a N-hydroxyeethyl amide moiety and it can be concluded that hydrolysis under environmental conditions (pH 4 to 9, 12 deg C) is comparable to N-Methyl acetamide mentioned before. Because of this extremely long half-life a hydrolysis study is not warranted.
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