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EC number: 696-317-2 | CAS number: 174489-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Initial weight of one female (102) was very slightly below the preferred range specified in the General Study Plan (200 - 300 g). This deviation has no impact on the integrity of the test.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- prop-2-en-1-yl 2-(2-chloro-5-nitrobenzoyloxy)-2-methylpropanoate
- EC Number:
- 696-317-2
- Cas Number:
- 174489-76-0
- Molecular formula:
- C14H14ClNO6
- IUPAC Name:
- prop-2-en-1-yl 2-(2-chloro-5-nitrobenzoyloxy)-2-methylpropanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd. Biotechnology & Animal Breeding Division. 4414 Füllinsdorf / Switzerland
- Age at study initiation: Young adult (approximately 8 - 12 weeks)
- Weight at study initiation: 199.9 - 238.2 g
- Fasting period before study:
- Housing: Individual
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22± 3°C
- Humidity (%): 50 % ± 20 %
- Air changes (per hr): Approximately 13 - 14/hour
- Photoperiod (hrs dark / hrs light): 12/12 hours
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6cm x 6cm
- % coverage: 10%
- Type of wrap if used: Gauze-lined semiocclusive dressing fastened around the trunk with an adhesive elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Skin cleaned with lukewarm water.
- Time after start of exposure: 24 hours.
TEST PROCEDURE
- Dose level: 2000 mg/kg.
- Ratio test item to vehicle: 8001.3 mg test item moistened with 8000 mg vehicle.
- Quantity applied: 400 mg per 100g body weight. - Duration of exposure:
- 24 hours
- Doses:
- 1 single dose.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- OBSERVATIONS AND RECORDS
Period of observation: 14 days after end of treatment.
Clinical observations: Checked and recorded individually within the first two hours after dosing, then daily for the duration of the observation period.
Local tolerances: The application site examined daily for signs of dermal irritation. Any deviations from normal were recorded using the Draize scale.
Body weight: Measured and recorded immediately before dose administration, on days 7 and 14.
Results and discussion
- Preliminary study:
- The dose level of 2000 mg/kg for the limit test was selected based on the OECD/EEC guidelines and pre-test results.
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality in the study.
Threrefore, the following acute dermal LD50 values were determined for CA 2218 A (Intermediate CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight - Clinical signs:
- other: There were no clinical signs indicative of treatment-related effects for any animal.
- Gross pathology:
- Necropsy examinations revealved no observable abnormalities.
- Other findings:
- There were no remarkable findings at the application site for any animal.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The following acute dermal LD50 values were determined for CA 2218 A Intermediate of CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight - Executive summary:
Groups of 5 male and 5 female rats were administered a single dose of CA 2218 A (Intermediate CGA 276854), batch no. OP 802002, by dermal application at a dose level of 2000 mg/kg for 24 hours under semiocclusive conditions, followed by a 14 day post treatment observation period.
There was no mortality in the study.
There were no clinical signs indicative of treatment-related effects nor were there any remarkable findings at the application site for any animal.
A slight loss of body weight was recorded in two females during the first week after treatment.
Necropsy examinations revealed no observable abnormalities.
The following acute dermal LD50 values were determined for CA 2218 A Intermediate of CGA 276854):
LD50in male rats: Greater than 2000 mg/kg body weight
LD50in female rats: Greater than 2000 mg/kg body weight
LD50in rats of both sexes: Greater than 2000 mg/kg body weight
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