Registration Dossier
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EC number: 604-045-2 | CAS number: 137862-53-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sep - Oct 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 10.7 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20 °C
- pH:
- 3.8
- Details on results:
- The saturation concentration of CGP 48933 Step 9 was determined to be 11.3 mg/I± 0.6 mg/I standard deviation in the first experiment and 10.2 mg/I± 0.3 mg/I standard deviation in the second experiment.
The relativ standard... deviation of each 7 consecutive samples was calculated to be 3 - 5 % during the experiments. 1'he variation between the water solubilities as determined during the low flow rate (first experiment) and the high flow rate was calculated to be< 10 %. According to the guidelines, the criteria of< 30 % were met and therefore the test was considered to be valid.
The linearity of the analytical method was proved in the concentration range from 1.45 μg/ml to 14.5 μg/ml. - Conclusions:
- The water solubility of CGP 48933 Step 9 was determined to be on avarage 10.7 mg/I at 20.0 °C ± 0.5 °C using the column elution method.
Reference
Solvent |
Temp (°C) |
Resulting pH |
Solubility (g/L) |
water |
25 |
3.8 |
0.18 |
0.2 M NaCl |
25 |
3.8 |
0.18 |
0.1 N HCl |
22 |
1.12 |
0.084 |
0.01 M glycine buffer, pH = 3 |
22 |
3.05 |
0.104 |
0.067 M phosphate buffer, pH = 5.2 |
22 |
4.41 |
0.64 |
0.067 M phosphate buffer, pH = 6.0 |
22 |
4.90 |
2.82 |
0.067 M phosphate buffer, pH = 7.4 |
22 |
5.26 |
14.4 |
0.067 M phosphate buffer, pH = 8.0 |
22 |
5.29 |
16.8 |
water |
37 |
3.8 |
0.21 |
0.01 N HCl |
37 |
1.0 |
0.10 |
Description of key information
The water solubility of CGP 48933 Step 9 was determined to be on avarage 10.7 mg/L at 20.0 °C ± 0.5 °C using the column elution method.
Key value for chemical safety assessment
- Water solubility:
- 10.7 mg/L
- at the temperature of:
- 20 °C
Additional information
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