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Diss Factsheets
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EC number: 470-680-5 | CAS number: 958872-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key study: The estimated bioaccumulation factor for these two metabolites using the software BCFWIN v2.17 is as follows:
M1 = BCF = 3.162 (based on estimated log Kow 3.22)
M2 = BCF = 106.09 (based on estimated log Kow 3.54)
Key value for chemical safety assessment
Additional information
The results obtained in the study “Identification of Degradation Products in Test Samples of a Ready Biodegradability DOC Die Away Test” revealed the two major metabolites to be acids of the parent compound; 2-(2-bornyloxy)-propionic acid (M1) and 2-[2-(2-bornyloxy)-1/2-methyloxy]-propionic acid (M2).
These more exhaustive analyses show that the parent chemical was completely degraded during the OECD 301A guideline test. The slower rate of complete mineralization (i.e., to achieve the threshold for “Ready Biodegradable”) is explained by the fact that the test substance can be totally degraded without the loss of DOC in the biodegradability test, and it is only in subsequent steps in the metabolism that loss of DOC would be expected to be observed in the standard test that measures bulk DOC loss. The presence of two methoxypropionic acids and no other polar metabolites is consistent with the assessment that metabolism of the test substance to the corresponding acid is rapid, that metabolism of propionic metabolites is a slower process, and that metabolism of the isobornyl moiety is rapid. Since less than 20% of the DOC within the test substance is associated with the oxidation and hydrolysis of the propionic acids, the loss of over 50% of the DOC in the original test suggests that complete mineralization of the propionic acid metabolites was occurring after the rate-controlling step. This degradation pattern, with only non-bioaccumulative and non-toxic polar intermediates of these isobornyl ethers is similar to biodegradation of natural plant materials and humic acids, which are vital components of our natural waters.
The estimated bioaccumulation factor for these two metabolites using the software BCFWIN v2.17 is as follows:
M1 = BCF = 3.162 (based on estimated log Kow 3.22)
M2 = BCF = 106.09 (based on estimated log Kow 3.54)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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