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EC number: 213-180-2 | CAS number: 928-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48 h-EC50 (immobilisation) to Daphnia magna is 3.67 mg/L under static conditions (95% CI 3.02 to 4.62 mg/L) in accordance with OECD 202 under GLP.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.67 mg/L
Additional information
The key study was conducted in accordance with OECD 202 under GLP to determine the aquatic acute toxicity of the test substance potassium isopentyl dithiocarbonate (PIAX) to Daphnia magna. The observed 48 h-EC50 (immobilisation ) to Daphnia magna was 3.67 mg/L (95% CI 3.02 to 4.62 mg/L) based on nominal concentrations. Potassium dichromate was used as a reference substance. The stability of PIAX was monitored as TOC, and as 94 % was recovered after 48 hours, the substance was concluded to fulfil the stability criteria of the method. Therefore it was concluded that the nominal concentrations could be used instead of measured concentrations to verify the effect levels of the study. The study was considered as reliable without restrictions and hence used as a key value for hazard assessment and classification and labelling of the substance. The study was considered as reliable without restrictions and hence can be used as a key value for hazard assessment and classification and labelling of the substance.
A 24 -h EC50 to Daphnia magna was determined for PIAX also by Xu et al. (1988) to be 3.0 mg/L at 20 oC at pH of 8.4 in accordance with OECD 202. In that study potassium PIAX and the other two xanthates tested were 10 times less toxic than potassium ethyl xanthate. As the results are taken from a peer reviewed publication with basic information on test materials and methods, they are rated as scientifically acceptable, and support the result of the key study.
Hawley (1977) reviewed older acute toxicity data of short term bioassays. The 96-h median tolerance level in Daphnia magna was expected to lie in the range 0.1 - 1.0 mg/L on a read-across substance PAX. Leduc et al. (1974) reported a single 48-h LC50value to Daphnia magna in the range 0.01 - 0.16 mg/L in a static system also on PAX, and compared it to other acute aquatic toxicity values obtained. As the details of the test materials, methods and study results, including statistics and controls are not available in the both of these reports,the results obtained are rated as not reliable, but suggest daphnids being the most sensitive species regarding the acutely toxic aquatic effects.
Available EC/IC50 -values of degradation products 3-methylbutan-1 -ol and pentanol are > 100 mg/L for daphnids and freshwater ciliata. For CS2, a 48 -h EC50 on Daphnia magna (immobilisation) was 2.1 mg/L in a semi-static acute immobilisation test.
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