Registration Dossier
Registration Dossier
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EC number: 606-947-1 | CAS number: 221640-21-7
Endpoint summary
Administrative data
Description of key information
Skin sensitisation (LLNA, mouse): not sensitising [Leidenfrost 2016]
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a dermal sensitization study according to OECD TG 429 (24 April 2002) with Triamine Dihydrochloride in Dimethylformamide, young adult female NMRI Mice (6/dose) were tested in the LLNA (OECD TG 429). Up to 30% of the test item was applied. Hexyl cinnamic aldehyde (CAS No 101-86-0) was used as positive control substance. Only after treatment with the positive control, alpha hexyl cinnamic aldehyde, the NMRI mice showed statistically significant increases in the weights of the draining lymph nodes and in the stimulation indices for cell counts compared to vehicle control animals.
This study did neither point to a non-specific (irritant) nor to a specific immunostimulating (sensitizing) potential of the test item. This applies to NMRI mice, for weight and cell count indices of the draining lymph nodes as well as ear swelling and ear weight indices evaluated after application of the test substance. In this study, the test item is not a dermal sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Skin sensitisation:
Based on the available study result (non-sensitising) a classification according to regulation (EC) No 1272/2008, Annex I, is not warranted.
Respiratory sensitisation:
No da available.
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