Registration Dossier
Registration Dossier
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EC number: 229-222-8 | CAS number: 6440-58-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Reliable (Klimisch 1) toxicity studies with microorganisms have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Ciliutti (2003) provides an estimated 72hr EC50 of >100 mg/L and the NOEC was 100 mg/L based on growth using DMDMH. Consequently this value will be taken as the toxicity in microorganisms endpoint for DMDMH.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Reliable (Klimisch 1 or 2) toxicity studies with microorganisms have been conducted for DMDMH or the hydrolysis product of DMDMH, DMH and are included in this dossier. Studies conducted with the hydrolysis product, DMH, are considered relevant for environmental fate and ecotoxicology and are considered in this dossier.
Ciliutti (2003)conducted a reliable (Klimisch 1) GLP compliant study following OECD 209 methods. Synthetic sewage feed inoculated with activated sludge was exposed to concentrations of DMDMH (100, 50.0, 25.0, 12.5 and 6.30 mg/L) and incubated for 3 hours. The 3hr EC50 and NOEC, based on respiration rate, were >100 mg/L and 100 mg/L, respectively.
Clark (2007) conducted a reliable (Klimisch 1) GLP compliant study following OECD 209 methods. Synthetic sewage feed inoculated with activated sludge was exposed to one concentration of DMH, the hydrolysis product of DMDMH (1000 mg/L) and incubated for 3 hours. The 3hr EC50 and NOEC, based on respiration rate, were >1000 mg/L and 1000 mg/L, respectively.
Reliable (Klimisch 1) toxicity studies with microorganisms have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Ciliutti (2003) provides an estimated 72hr EC50 of >100 mg/L and the NOEC was 100 mg/L based on growth using DMDMH. Consequently this value will be taken as the toxicity in microorganisms endpoint for DMDMH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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