Registration Dossier
Registration Dossier
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EC number: 210-155-8 | CAS number: 608-25-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-methylresorcinol
- EC Number:
- 210-155-8
- EC Name:
- 2-methylresorcinol
- Cas Number:
- 608-25-3
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-methylbenzene-1,3-diol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: moistened
- Amount / concentration applied:
- 0.5 gram
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 1, 24, 48, 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: application of the undiluted test substance resulted in very slight erythema in the treated skin-area of one out of the three treated rabbits one hour after instillation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
Any other information on results incl. tables
Guideline: OECD 404
Species: New Zealand White rabbits
Group: 3 males
Test substance: 2 -methylresorcinol
Purity: 98.6%
Dose: 0.5g
GLP: in compliance
An aliquot of 0.5 g of the moistened test substance was exposed to the intact shaved back
skin of each animal for 4 hours under semi-occlusive conditions. Animals were examined
approximately 1 hour, 24, 48 and 72 hours after termination of the exposure.
Results
The test substance caused orange staining of the skin but the investigators said that this did
not affect observations.
Under the conditions of the study, application of the undiluted test substance resulted in
very slight erythema in the treated skin-area of one rabbit one hour after instillation.
Conclusion
The test substance applied undiluted to rabbit skin showed mild and transient skin irritation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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