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EC number: 604-669-5 | CAS number: 149021-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2-propylheptyl acrylate was irritant to the skin but not to the eye. 2-propylheptyl acrylate may be irritating to the respiratory system.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-01-11 to 2008-02-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to OECD TG No. 404 and in compliance with GLP regulations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- April 24, 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Rabbits / New Zealand white A 1077 INRA (SPF) from Centre Lago S. A., 01540 Vonnas, France
- Age at study initiation: 7 – 8 months
- Weight at study initiation: 3.78 kg – 4.36 kg
- Housing: Single housing in stainless steel wire mesh cages with grating, floor area: 3000 cm2. The animals were housed in fully air-conditioned rooms.
- Diet: Kliba-Labordiaet (Kaninchen & Meerschweinchenhaltung “GLP”), Provimi Kliba SA, Kaiseraugst, Basel, Switzerland (about 130 g/animal per day)
- Water: tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20 – 24°C
- Humidity: 30 – 70%
- Photoperiod (hrs dark / hrs light): 12 h / 12 h (6.00 a.m. – 6.00 p.m. / 6.00 p.m. – 6.00 a.m.)
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted test substance
- Duration of treatment / exposure:
- Exposure for 4 h.
- Observation period:
- Immediately after removal of the patch, approx. 1, 24, 48 and 72 h after removal of the patch and then in weekly intervals maximally up to day 14.
- Number of animals:
- 3 animals (2 male/1 female)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: The test substance was covered with a test patch (Idealbinde, Pfaelzische Verbandstoff-Fabrik, Kaiserslautern) and Fixomull® stretch (adhesive fleece), Beiersdorf AG
REMOVAL OF TEST SUBSTANCE
- Washing: The test substance was removed at the end of the exposure period with Lutrol® and Lutrol®/water (1 : 1).
- Time after start of exposure: 4h
SCORING SYSTEM:
According to OECD guideline 404 - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 2.9
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24-72 h
- Score:
- 3.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24-72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24-72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24-72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritant / corrosive response data:
- Mean scores over 24, 48 and 72 hours for each animal were 2.3, 3.3 and 3.0 for erythema and 0.3, 1.3 and 1.3 for edema (see table 1).
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Table 1: Individual cutaneous examinations and mean values.
|
|
Exposure period 4 h |
||
Animal |
Erythema |
Edema |
Additional findings |
|
0 h |
1 |
2 |
0 |
|
|
2 |
2 |
0 |
|
|
3 |
2 |
0 |
|
1h |
1 |
2 |
0 |
15 |
|
2 |
2 |
1 |
15,16 |
|
3 |
2 |
1 |
15,16 |
24 h |
1 |
3 |
1 |
15,16 |
|
2 |
4 |
2 |
15,16 |
|
3 |
4 |
2 |
15,16 |
48 h |
1 |
2 |
0 |
15 |
|
2 |
3 |
1 |
15,16 |
|
3 |
3 |
1 |
15,16 |
72 h |
1 |
2 |
0 |
15 |
|
2 |
3 |
1 |
15,16 |
|
3 |
2 |
1 |
15,16 |
7 d |
1 |
2 |
0 |
S, 15, 17 |
|
2 |
2 |
0 |
S, 15, 17 |
|
3 |
2 |
0 |
S, 15, 17 |
14 d |
1 |
2 |
0 |
S, 15, 17 |
|
2 |
2 |
0 |
S, 15, 17 |
|
3 |
2 |
0 |
S, 15, 17 |
Mean 24 – 72 h |
1 |
2.3 |
0.3 |
|
|
2 |
3.3 |
1.3 |
|
|
3 |
3.0 |
1.3 |
|
Mean |
|
2.9 |
1.0 |
|
|
|
15: erythema extending beyond the area of exposure |
||
|
|
16: edema extending beyond the area of exposure |
||
|
|
S: scaling 17: scaling extending beyond the area of exposure |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-01-11 to 2008-02-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to OECD TG No. 405 and in compliance with GLP regulations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Rabbits / New Zealand white A 1077 INRA (SPF) from Centre Lago S. A., 01540 Vonnas, France
- Age at study initiation: 5 – 6 months
- Weight at study initiation: 3.52 kg – 4.03 kg
- Housing: Stainless steel wire mesh cages with grating, floor area: 3000 cm². Single housing.
- Diet: Kliba-Labordiaet (Kaninchen & Meerschweinchenhaltung “GLP”), Provimi Kliba SA, Kaiseraugst, Basel, Switzerland (about 130 g/animal per day)
- Water: Tap water ad libitum
- Acclimation period: at least 5 days before application
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24°C
- Humidity: 30-70%
- Photoperiod (hrs dark / hrs light): 12 h / 12 h (6.00 a.m. – 6.00 p.m. / 6.00 p.m. – 6.00 a.m.) - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated left eye of the animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL
- Concentration: undiluted - Duration of treatment / exposure:
- Exposure for 24 h.
- Observation period (in vivo):
- 72 h (the study was discontinued since all animals were without findings 48 h after test start)
- Number of animals or in vitro replicates:
- 3 animals (2 female, 1 male)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: rinsed with 3 to 6 mL of hand warm tap water for 1 to 2 minutes using a syringe with a blunt probe.
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize scoring system according to OECD Tg 405
TOOL USED TO ASSESS SCORE:
-Daylight tubes "Lumilux" (L 58W/860 PLUS ECO 25X1, Osram, Germany)
Readings:
Approx. 1, 24, 48 and 72 h after application.
Mortality check:
A check for any dead or moribund animal was made twice each workday (at the beginning and end of work) and once daily at weekends and on public holidays.
Evaluation/Scoring:
The evaluation is based on the criteria of the Commission Directive 67/548/EEC and the OECD Harmonized Integrated Classification System that were in place on the date of report signature. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effect
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0.1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effect
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effect
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24-72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- Moderate conjunctival redness (grade 2) was noted in all animals 1 hour after application and decreased to slight (grade 1) in one animal until the 24-hour reading. Moderate or severe discharge (grade 2 or 3) was noted in all animals 1 hour after application, only. In addition injected scleral vessels ina circumscribed area or circular were noted during the observation period.
The ocular reactions were reversible in two animals within 24 hours and in one animal within 48 hours after application.
Mean scores calculated for each animal over 24, 48 and 72 hours were 0.0 for corneal opacity and for iris lesions, 0.0, 0.0 and 0.3 for redness of the conjunctiva and 0.0 for chemosis. (see details in table 1)
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Table 1: Individual ocular examinations and mean values.
Readings |
Animals |
Cornea |
|
Iris |
Conjunctiva |
|
|
Additional findings |
|
|
Opacity |
Area of cornea involved |
|
Redness |
Chemosis |
Discharge |
|
1 h |
1 |
0 |
0 |
0 |
2 |
0 |
0 |
scleral vessels injected, circumscribed area |
2 |
0 |
0 |
0 |
2 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
2 |
0 |
0 |
scleral vessels injected, circular |
|
24 h |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
1 |
0 |
0 |
scleral vessels injected, circumscribed area |
|
48 h |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
72 h |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Mean 24-72 h |
1 |
0.0 |
|
0.0 |
0.0 |
0.0 |
0.0 |
|
2 |
0.0 |
|
0.0 |
0.0 |
0.0 |
0.0 |
|
|
3 |
0.0 |
|
0.0 |
0.3 |
0.0 |
0.0 |
|
|
Mean |
|
0.0 |
|
0.0 |
0.1 |
0.0 |
0.0 |
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
In a test conducted in accordance to OECD TG No. 404, undiluted 2-propylheptyl acrylate was irritating to the skin of rabbits, when applied to 3 animals (two males, one female) for 4 hours under semiocclusive conditions. At the end of the observation period erythema (grades 2-3 of the Draize scoring system) were still present, while no edema was observed. All animals showed scaling at the end of the observation period. Mean erythema and edema scores (24-72 h) were 2.9 and 1.0, respectively. Erythema and edema were most severe at 24 h after the end of exposure (grades 4 and 2) and slowly decreased in intensity during the following days. Between 7 and 14 days after end of exposure no further decrease of erythema intensity was observed. Based on this study the test substance is irritating to the intact skin of New Zealand white rabbits (BASF SE, 2008).
Eye irritation:
In a test conducted in accordance to OECD TG No. 405, undiluted 2-propylheptyl acrylate (0.1 mL) was instilled into the eye of 2 female and 1 male rabbit for 24 h that followed rinsing for 1-2 minutes with 3-6 mL water. Moderate conjunctival redness (grade 2) was noted in all animals 1 hour after application and decreased to slight (grade 1) in one animal until the 24-hour reading. Moderate or severe discharge (grade 2 or 3) was noted in all animals 1 hour after application, only. In addition injected scleral vessels were observed in one animal at the readings after 1 h and 24 h, and in a second animal at the reading after 1h after beginning of exposure.
The ocular reactions were reversible in two animals within 24 hours and in one animal within 48 hours after application. Mean scores calculated for each animal over 24, 48 and 72 hours were 0.0 for corneal opacity and for iris lesions, 0.0, 0.0 and 0.3 for redness of the conjunctiva and 0.0 for chemosis. Based on this study 2-propylheptyl acrylate is not irritant to the eye. (BASF SE, 2008).
Respiratory irritation:
There exists no standard test method for the assessment of respiratory irritation. 2-propylheptyl acrylate has shown a skin irritating potential, whereas no irritation to the eye was observed. The structural analogue 2-ethylhexyl acrylate is classified as irritating to skin and respiratory tract. These data indicate a potential for respiratory irritation of 2-propylheptyl acrylate.
Justification for selection of skin irritation / corrosion endpoint:
GLP and guideline compliant study.
Justification for selection of eye irritation endpoint:
GLP and guideline compliant study.
Effects on skin irritation/corrosion: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
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