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EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 01, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD109) with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- OECD harmonised ring method
Test material
- Reference substance name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 213-485-0
- EC Name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 957-68-6
- Molecular formula:
- C10H12N2O5S
- IUPAC Name:
- (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: 7-Aminocefalosporansäure (7-ACA)
Lot no.: B146988
Constituent 1
Results and discussion
Surface tension
- Surface tension:
- 65 mN/m
- Temp.:
- 20 °C
- Conc.:
- 554.22 mg/L
Any other information on results incl. tables
The results of two measurements are summarized inTable1.
Table1: Measured surface tension values
Value No. |
1stmeasurements s[mN/m] |
2ndmeasurement s[mN/m] |
1 |
64.71 |
65.21 |
2 |
64.71 |
65.22 |
3 |
64.70 |
65.21 |
4 |
64.69 |
65.20 |
5 |
64.69 |
65.20 |
6 |
64.69 |
65.20 |
Mean value of the individual values |
64.70 |
65.21 |
Total mean value |
64.95 |
The test item has a mean surface tension of 65.0 mN/m. Therefore the test item is not to be regarded as surface active.
Applicant's summary and conclusion
- Conclusions:
- According to OECD Test Guideline 115 and EC No. 440/2008 Part A. Method A.5. the surface tension at 20 °C of test item 7-Aminocephalosporanic acid was determined to be:
= 65.0 mN/m
The test item is not to be regarded as surface active. - Executive summary:
Before the measurement the apparatus was cleaned very carefully. The measurement vessel was cleaned with double-distilled water and subsequently dried. The ring was rinsed with water to remove any water soluble substances, washed in double-distilled water and briefly heated over a flame.
The tensiometer was calibrated using a mass of 550 mg to obtain the calibration factorsafor multiplying all the instrument readings, which was done automatically.
For two tests solutions of the test item were prepared in distilled water. To obtain a concentration of 90 % of the saturation solubility 4 mL distilled water were added to 36 mL of a test solution (c = 615.8 mg/L) of the water solubility test of project CSL-12-0645.05. The concentration of the measured 90 % solutions was 554.22 mg/L.
The 90 % solution to be measured was transferred to the measurement vessel and the measurement vessel was placed on the table of the test apparatus. The temperature was adjusted to 20 °C.
The measurement vessel was raised automatically until the ring was immersed below the surface of the solution. Subsequently, the table top was lowered automatically to detach the ring from the surface until the maximum force was reached. The force was read on the tensiometer. The liquid layer attached to the ring was not separated from the ring.
After completing the first measurement, measurements were repeated until a constant surface tension value was reached.
The obtained surface tension values, presented by the tensiometer, are corrected values. The “really” measured values were first multiplied with the calibration factor and corrected afterwards by another correction factor depending on the ring dimensions, the density of the liquid and its surface tension. The corrections were automatically performed by the Tensiometer according to Zuidema & Waters.
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