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Diss Factsheets
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EC number: 211-720-1 | CAS number: 691-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There is no key study for the toxicokinetics of 4-methylpent-1-ene and as such the toxicokinetic assessment is based upon the available study data. The following sections were assessed:
Absorption
Distribution
Metabolism
Excretion
Key value for chemical safety assessment
Additional information
Toxicokinetics:
There is no key study for the toxicokinetics of 4-methylpent-1-ene and as such the toxicokinetic assessment is based upon the available study data.
Absorption
As the test substance is a low molecular weight organic molecule which is water soluble (34.1 mg/L at 20°C), a liquid at room temperature, volatile (vapour pressure of 37.7 kPa at 25 °C) and has a Log Kow of 3.38, it has the potential to be readily absorbed following oral, dermal and inhalation exposure. In the acute oral toxicity study no deaths occurred, no signs of toxicity were observed, body weight increases were regular and there were no abnormal findings at necropsy (Unknown, 2005). However, during an OECD 422 study histopathological effects were seen in the kidneys, which indicate that oral absorption is occurring (N/A, 2004). There is no data on dermal or inhalation absorption.
No human data is available.
Distribution and excretion
Based upon the effects seen in the kidneys in the OECD 422 study, for example the slight hyaline depositions in proximal tubular epithelium, the slight accumulation of eosinophilic body observed in proximal tubular epithelium, it is likely that a high proportion of the substance is distributed systemically following oral absorption. However, there were no findings in the urinalysis.
No human data is available.
Metabolism and Excretion
No information on the metabolism of the substance is available.
According to the results from the OECD 422 study, it is considered that the substance has no potential to accumulate and is therefore excreted immediately.
No human data is available.
Extrapolation to human
No human data on the toxicokinetics of the test substance have been identified.
References
· Unknown (2005). "Acute oral toxicity study of 4-methyl-1-pentene on Rat." Office of Chemical Safety, Evaluation and licensing Division, Pharmaceutical and Food Safety Bureau, Ministry of Health, Labour andWelfare
· N/A (2004). "4- METHYLPENT-1-ENE: ORAL (GAVAGE) COMBINED REPEATED DOSE TOXICITY STUDY WITH REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST IN THE RAT." Safety Research Institute for Chemical Compounds Co., Ltd.
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