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Diss Factsheets
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EC number: 448-100-7 | CAS number: 70441-63-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Mar - 05 Apr 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- Version / remarks:
- 1992-07-17
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 448-100-7
- EC Name:
- -
- Cas Number:
- 70441-63-3
- Molecular formula:
- C9H12FN
- IUPAC Name:
- 4-fluoro-N-(propan-2-yl)aniline
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- -Source of inoculum/activated sludge: A mixed population of aquatic microorganisms (activated sludge) was obtained on 07 March 2005 from the aeration tank of sewage plant Leverkusen-Bürrig, Germany
-Preparation of inoculum/activated sludge for exposure: The activated sludge was washed twice and separated by centrifugation
- Concentration of sludge: 0.4 g/l - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 2 g/L
- Based on:
- test mat.
- Initial conc.:
- 100 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium
- Test temperature: 20-25 °C
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 2 L glass vessels
- Number of culture flasks/concentration: 2 vessels and one concentration
SAMPLING
- Sampling frequency: DOC degradation was measured at 0h, 3h, 1, 7, 14, 21, 27, and 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 vessels
- Toxicity control: 1 vessel
- Reference control: 2 vessels
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 18
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- see details on results
BOD5 / COD results
- Results with reference substance:
- Points of degradation plot (reference substance):
99 % degradation after 28 d
Any other information on results incl. tables
Table 1. Results DOC Degradation given as mean of mean results
Test vessel |
% Degradation after n days |
||||||
|
3h |
1 d |
7 d |
14 d |
21 d |
27 d |
28 d |
Test compound |
0 |
1 |
0 |
7 |
12 |
18 |
18 |
Reference compound |
0 |
94 |
100 |
99 |
100 |
100 |
99 |
Toxicity control |
0 |
41 |
48 |
50 |
54 |
57 |
57 |
Table 2. Validity criteria OECD 302 B
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
The reference compound has been degraded≥70 % within 14 days. |
99 % degradation |
Yes |
No toxicity has been observed in the toxicity coontrol. |
57% after 28 d |
Yes |
The DOC content oft the blank control should be ≤10 mg/l in the beginning. |
< 5 mg/l |
Yes |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- See Table 2 in any other information on results incl. tables
- Interpretation of results:
- not readily biodegradable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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