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EC number: 263-171-2 | CAS number: 61791-39-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 August 1990 to 13 September 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs.
- EC Number:
- 263-171-2
- EC Name:
- 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-nortall-oil alkyl derivs.
- Cas Number:
- 61791-39-7
- Molecular formula:
- Not applicable (a generic molecular formula cannot be provided for this specific UVCB substance).
- IUPAC Name:
- 2-{2-[(8Z)-heptadec-8-en-1-yl]-4,5-dihydro-1H-imidazol-1-yl}ethan-1-ol; 2-{2-[(8Z)-heptadec-8-en-1-yl]-4,5-dihydro-1H-imidazol-1-yl}ethyl (9Z)-octadec-9-enoate
- Details on test material:
- - Name of test material (as cited in study report): EH & S 588
- Lot/batch No.: V0G188
- Other: Lab ID number: 90-0156
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Research Products, Inc., Denver PA
- Age at study initiation: Young adult
- Weight at study initiation: 2-3 kg
- Fasting period before study:
- Housing: Each animal was housed in a wire mesh cage.
- Diet: ad libitum; Agway ® ProLab Rabbit Formula (Agway, Inc., Syracuse, NY)
- Water: ad libitum; fresh tap water
- Acclimation period: five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not stated
- Humidity (%): Not stated
- Air changes (per hr): Not stated
- Photoperiod (hrs dark / hrs light): 12 hour light-dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- EXPOSURE CALCULATION
The approximate area dosed on each rabbit was 130cm2. Based on an average body weight of 2.13 kg times the dose level of 2000 mg/kg, the average dose was determined to be 4260 mg. Therefore, the approximate amount of test material applied per unit of exposed skin was calculated to be 32.8 mg/cm2.
TEST SITE
The fur on the back of each rabbit was clipped with electric clippers on the day prior to dose administration. The test article was applied topically to the clipped area at a dose level of 2000 mg/kg body weight. Each test site was covered with gauze and then occluded with a layer of plastic wrap and a stockinette sleeve held in place with tape.
REMOVAL OF TEST SUBSTANCE
The binders were removed 24 hours after dose administration and the exposure sites gently wiped with a clean water-moistened gauze to remove as much non-absorbed test article as possible. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg /kg body weight
- No. of animals per sex per dose:
- five male and five female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed for pharmacotoxic signs and mortality three times on the day of dose administration and twice daily thereafter. Individual bodyweights were recorded prior to dose administration on study day 1 and on days 4, 8 and 15 (study termination).
- Necropsy of survivors performed: yes; All animals were euthanized with an injection of sodium pentobarbitol on study day 15 and subjected to gross necropsy examination. The external body surface and orifices, major visceral organs, body cavities and the carcass were examined and the results recorded. No tissues were saved. - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 95% confidence limits not reported.
- Mortality:
- All animals survived to study termination.
- Clinical signs:
- other: A gel-like substance in the waste tray and soft stools.
- Gross pathology:
- No internal abnormalities were noted during gross necropsy examination of the animals. Gross necropsy confirmed eschar sloughing.
- Other findings:
- All animals appeared normal from study days 8-15. Test article application caused severe dermal irritation characterised by edema and eschar formation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the acute dermal LD50 of the test material is considered to be greater than 2000 mg/kg body weight.
- Executive summary:
The test material was applied topically to five male and five female New Zealand White Rabbits at a dose level of 2000 mg/kg body weight for a period of 24 hours. The animals were observed for pharmacotoxic signs and mortality during a 15 day observation period.
All animals survived to study termination (day 15). Under the conditions of this study, the acute dermal LD50 of the test material is considered to be greater than 2000 mg/kg body weight.
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