Registration Dossier
Registration Dossier
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EC number: 606-946-6 | CAS number: 221640-14-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- other: Knudsen effusion method
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.001 Pa
- Conclusions:
- The vapor pressure of carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) is lower than 0.001 Pa obtained at 25°C.
- Executive summary:
The vapor pressure of carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) was determined using a screening method based on the detection of the evaporation rate from a Knudsen cell of a vapor pressure balance at 25°C. The method corresponds to the Knudsen effusion method as described in the EC Testing Guideline A.4.
Since the evaporationrate was below the value derived from the lower lirnit of the vapor pressure range recommended for the use of a vapor pressure balance (10-3 Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure of carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) is lower than 10-3 Pa.
Reference
The evaporationrate is deterrnined from the increase in weight per unit time from which the vapor pressure is calculated with the following Hertz-Knudsen- Langmuir equation. The evaporationrate was below the value derived from the lower lirnit of the vapor pressure range recommended for the use of a vapor pressure balance (10-3 Pa, EC Testing Guideline A.4).
Description of key information
The vapor pressure of carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) is lower than 0.001 Pa obtained at 25°C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.001 Pa
- at the temperature of:
- 25 °C
Additional information
"Should read: < 0.001 Pa"
Since the evaporationrate was below the value derived from the lower lirnit of the vapor pressure range recommended for the use of a vapor pressure balance (10-3 Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure is lower than 10-3 Pa.
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