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EC number: 478-310-4 | CAS number: 53803-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 478-310-4
- EC Name:
- -
- Cas Number:
- 53803-13-7
- Molecular formula:
- C9H21NO2
- IUPAC Name:
- Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid
- Test material form:
- other: Liquid
- Details on test material:
- Test was performed using commercial product DABCO TMR-7 which is 50% solution of Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid in 1,2-ethandiol, Batch #19847-85
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Ethane-1,2-diol
- Doses:
- Animals were dosed orally at the doses 50, 300, 500, 2000 mg/kg b.w.
- No. of animals per sex per dose:
- Initially three female rats were dosed at 2 000mg/kg b.w. Based on the response following doses were applied
Dose Male/Female treated Mortality
50 mg/kg 0/3 NA/0
300 mg/kg 3/3 1/1
500 mg/kg 0/3 NA/3
2000 mg/kg 0/3 NA/3 - Control animals:
- no
- Details on study design:
- Initially three female rats were dosed at 2 000mg/kg b.w. Based on the response additional groups of animals were dosed.
Animals were observed 0.5, 1, 2.3.4 hours postdose and then once daily for 14 days for mortality, toxicity and pharmacological effects.
Results and discussion
- Preliminary study:
- Initially three female rats were dosed at 2 000mg/kg b.w. All3 animals died within 3 minutes from dosing.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 165 mg/kg bw
- Based on:
- test mat.
- Mortality:
Dose Male/Female treated Mortality
50 mg/kg 0/3 NA/0
300 mg/kg 3/3 1/1
500 mg/kg 0/3 NA/3
2000 mg/kg 0/3 NA/3- Clinical signs:
- other: 50 mg/kg - no signs 300 mg/kg - 1 male and 1 female died within 4 h, lethargy was the only sign observed 500 mg/kg - lethargy,sagging eyelids, all 3 animals died within 2 h
- Gross pathology:
- 50 mg/kg - normal
300 mg/kg - dead animals - abnormalities in lungs, liver, spleen, stomach, brown staining in nose/mouth, survivors - 3 animals had normal results, 1 animal had mottled kidneys
500 mg/kg - abnormalities in lungs, kidneys and spleen
2000 mg/kg - 2 animals no findings, 1 animal red areas on the lungs
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of the 50% solution of Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid in 1,2-ethandiol is 330 (235-464) mg/kg bw. The estimated oral LD50 of the Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid is therefore 165 mg/kg b.w.
- Executive summary:
Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid acute oral toxicity was tested with the result LD50 ca 165 mg/kg b.w.
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