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Physical & Chemical properties

Partition coefficient

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Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
06 November 2012 to 18 January 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
> 9.4
Temp.:
30 °C
pH:
6.3
Details on results:
The result from the preliminary test indicated that the HPLC method was the most suitable for determination of partition coefficient for this test item.
The mobile phase’s pH was unadjusted as the test item had no dissociation constants in the environmentally relevant pH range and so was tested in its non-ionized form.
The chromatography of the test item showed one sharp main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, the test item was considered to be stable during the test procedure.
Conclusions:
The partition coefficient of the test item has been determined to be >2.51E+09, log10 Pow > 9.4.
Executive summary:

Method

The determination was carried out using the HPLC Method designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.

The test system consisted of a high performance liquid chromatograph with a suitable detector (UV/VIS, ELS). A reverse phase HPLC column with a very low percentage of polar groups was used (e.g. C8, C18). The mobile phase contained at least 25% aqueous phase.

Conclusion

The partition coefficient of the test item has been determined to be >2.51E+09, log10 Pow > 9.4.

Description of key information

The partition coefficient of the test item has been determined to be >2.51E+09 with Log10 Pow > 9.4 (OECD 117 and EU Method A.8).

Key value for chemical safety assessment

Additional information

The partition coefficient of the test item has been determined to be > 2.51 x 10E+09 with Log10 Pow > 9.4.