Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a very brief report in a secondary source is available on the unspecified isomer. Primary Russian publication (Volkova et al. 1998) could not be obtained

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
[Unknown]
Author:
Volkova NV et al.
Year:
1998
Bibliographic source:
Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia (Hazardous substances. Nature products), 285
Reference Type:
secondary source
Title:
Unnamed
Year:
2003

Materials and methods

Principles of method if other than guideline:
No data on methodology given in secondary source
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): pinane, 2,3-epoxy-
- Molecular formula (if other than submission substance): C10-H16-O
- Molecular weight (if other than submission substance): 152.235
- Smiles notation (if other than submission substance): C1([C@@H]2[C@@]3(O[C@@H]3C[C@@H]1C2)C)(C)C
- InChl (if other than submission substance): 1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3
- Structural formula attached as image file (if other than submission substance): see Fig. 1
- Substance type: no data in citing source
- Physical state: no data in citing source
- Analytical purity: no data in citing source
- Impurities (identity and concentrations): no data in citing source
- Composition of test material, percentage of components: no data in citing source
- Isomers composition: no data in citing source
- Purity test date: no data in citing source
- Lot/batch No.: no data in citing source
- Expiration date of the lot/batch: no data in citing source
- Stability under test conditions: no data in citing source
- Storage condition of test material: no data in citing source

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
No data in citing source
No. of animals per sex per dose:
No data in citing source
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2.4 mL/kg bw
Based on:
not specified
Remarks on result:
other: No exposure duration or confidence intervals given.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A secondary source (RTECS) provides limited details of an acute oral [presumably gavage] toxicity study conducted on rats given pinene alpha epoxide (unspecified isomer). The reported oral LD50 was 2.4 ml/kg bw [approximately 2.4 g/kg bw].
Executive summary:

A secondary source (RTECS) provides limited details of an acute oral toxicity study conducted on rats given pinene alpha epoxide (unspecified isomer) [presumably by gavage]. [The original Russian publication could not be obtained.] The reported oral LD50 was 2.4 ml/kg bw [about 2.4 g/kg bw].

According to the EU CLP and DSD regulations, this would not require classification for acute oral toxicity.