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Diss Factsheets
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EC number: 202-681-1 | CAS number: 98-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The elimination of the test item from the blood after intravenous injection and oral administration followed a triexponential equation with very rapid distribution in the tissues and a biological elimination half-life of about 20 hours. After oral administration of the test item via microencapsulated suspension or corn oil solution, the maximum blood levels were reached after 50 - 100 minutes or 8-11 hours respectively. The absorption hal-life was 17 minutes or 98 minutes respectively.
After oral administration of the test item via corn oil solution, a total exctretion of 79% (females) and 87% (males) was found after 4 days, but the main part (50-60%) was excreted already after 24 hours. The test item was excreted unchanged in exhalations and in faeces, while low levels of metabolites were found in urine. Only low levels of activity were found in the tissues after 4 days, mostly in adipose tissues.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
In PCBTF-exposed rats, most of the treatment dose was exhaled as unchanged PCBTF. The remainder was excreted as metabolites in the urine (dihydroxybenzotrifluoride and 4-chloro-3-hydroxybenzotrifluoride glucuronides, as well as minor amounts of a mercapturic acid conjugate) and feces. The vehicle used for oral dosing of test animals was shown to affect both the absorption rate and maximum blood concentration, but not bioavailability, distribution or elimination.
No absorption rate is available, however the maximum blood concentration was 40 microl/ml and was reached in 100 minutes or 11 hours according to the vehicle used.
From all the available studies, it is clear that the elimination of PCBTF is rapid and almost complete (up to 87% in 4 days; DT50 = less than one day). Very low levels have been found in adipose tissues. It is concluded therefore that PCBTF has no potential of bioaccumulating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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