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EC number: 266-380-7
CAS number: 66492-51-1
In an acute oral toxicity study performed according to the Acute Toxic
Class method, 2000 mg/kg bw of the undiluted test item were administered
to two test groups of three fasted Wistar rats by gavage. The following
test item-related clinical observations were recorded during the course
of the study:
· One out of six animals died
· Impaired general state
· The mean body weight of the animals increased within the normal range
throughout the study period with the exception of one female of the
first administration group, which showed reduction of body weight during
the first post-exposure week, but gained adequately weight during the
second postexposure week.
The following macroscopic pathological findings were recorded in the
animal that died:
· Stomach: filled with liquid content
· Glandular stomach: extensive bleeding
· Spleen: black discoloration in one-third
· Small intestine: red discoloration
· Content of the small intestine: red discoloration
· Kidneys: congestion
· There were no macroscopic pathological findings in the animals
sacrificed at the end of the observation period (5 females).
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