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EC number: 204-625-1 | CAS number: 123-41-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The water solubility was calculated using the OPERA calculation model.
- Water solubility:
- 4.64 other: mol/L
- Remarks on result:
- other: This is a calculation conducted using the OPERA calculation model. As such, the information on Temperature, pH can not be filled in.
- Conclusions:
- The water solubility of pure choline hydroxide was calculated to be 4.64 mol/L.
- Executive summary:
The water solubility of pure choline hydroxide was calculated with OPERA Model calculation. The water solubility was calculated to be 4.64 mol/L.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well-documented study (preliminary test / OECD 105 guideline) without deviations
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- other: visual inspections
- Water solubility:
- > 90 vol%
- Temp.:
- 22 °C
- pH:
- 14.2
- Remarks on result:
- other: Referring to a 45 % aqueous solution of choline hydroxide; the test item was confirmed as fully miscible
- Water solubility:
- > 486 g/L
- Temp.:
- 22 °C
- pH:
- > 14.2
- Remarks on result:
- other: recalculated via the density of the 45 % solution, which was possible because the test item did not reveal any precipitation from visual inspection
- Conclusions:
- Interpretation of results: very soluble (> 10000 mg/L)
The test substance and all test solutions were observed to contain no precipitate.
The water solubility of test substance Choline Base (as a 45 % aqueous solution) was confirmed as miscible in all proportions. It is therefore reasonable to calculate the water solubility of Choline Base assuming that the test substance is fully soluble in water as a 45 weight % solution in water:
45 weight % is equivalent to 450 g/kg x 1.08 g/L (Density of Test Solution) = 486 g/Litre.
This will be reported as a minimum solubility value of >486 g/Litre. - Executive summary:
The water solubility of a 45 % choline hydroxide (CB) solution was determined in a OECD 105 guideline study by visual inspection. All tested proportions ranging from 1:9 to 9:1 were reported fully miscible and no phase separation occured. Also, choline base as a 45 % solution did not exhibit any visual precipitation. This allows the conclusion that the water solubility of choline hydroxide is > 486 g CB / 1L water, so choline hydroxide is very soluble.
Referenceopen allclose all
Table 1: All test solution weighings, measurements and observations
Wt sample (g) | Soluble? | % w/w | Miscible? | pH |
1.0019 | 9.0145 | 10.00 | Yes | 13.10 |
2.0218 | 8.0179 | 20.14 | Yes | 13.35 |
3.0082 | 7.0246 | 29.98 | Yes | 13.51 |
4.0043 | 6.0252 | 39.93 | Yes | 13.62 |
5.0325 | 5.0037 | 50.14 | Yes | 13.73 |
6.0116 | 4.0157 | 59.95 | Yes | 13.83 |
7.0120 | 3.0171 | 69.92 | Yes | 13.94 |
8.0046 | 2.0251 | 79.81 | Yes | 14.06 |
9.0044 | 1.0001 | 90.00 | Yes | 14.20 |
pH of distilled water blank = 7.72
In addition the test substance and all test solutions were observed to contain no precipitate.
The water solubility oftest substance Choline Base was confirmed as miscible in all proportions as a 45 weight % solution in water. It is therefore reasonable to calculate the water solubility of Choline Base assuming that the test substance is fully soluble in water as a 45 weight % solution in water:
45 weight % is equivalent to 450 g/kg x 1.08 kg/L (Density of Test Solution) = 486 g/Litre.
This will be reported as a minimum solubility value of >486 g/Litre.
Description of key information
Water solubility (study conducted using a 45 % Choline hydroxide aqueous solution): very soluble, approx. ≥ 486 g Choline hydroxide / 1L water (according OECD 105, visual inspection)
Water solubility (pure choline hydroxide) calculated with OPERA Model: 4.64 mol/L.
Key value for chemical safety assessment
- Water solubility:
- 486 g/L
- at the temperature of:
- 22 °C
Additional information
The water solubility of a 45 % Choline hydroxide (CB) solution was determined in an OECD 105 guideline study by visual inspection. All tested proportions ranging from 1:9 to 9:1 were reported fully miscible and no phase separation occured. Also, Choline base as a 45 % solution did not exhibit any visual precipitation. This allows the conclusion that the water solubility of Choline hydroxide is > 486 g CB / 1L water, so Choline hydroxide can be considered as very soluble in further risk assessment.
The test was performed according OECD 105 guideline and the study is classified as Klimisch 1. The results are reasonable, within the scientifically expected ranges and can therefore be considered as reliable. Hence, the tonnage-driven data requirements under REACH are fully met, no datagaps were identified and no further testing is required.
In addition, the water solubility of pure choline hydroxide was calculated with OPERA Model calculation. The water solubility was calculated to be 4.64 mol/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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