Registration Dossier
Registration Dossier
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EC number: 202-088-8 | CAS number: 91-66-7
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
Bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of chemical on testorganism Cyprinus carpio.
Nominal concentrations used in the study are Nominal concentrations 1st Concentration area: 0.2 ppm(v/v), 2nd Concentration area: 0.02 ppm(v/v) and Range finding study was carried out on Rice fish (Oryzias latipes)TLm(48h) 16.8 ppm(w/v). The vehicle used in this study was HCO-40.The bioconcentration factor (BCF) for test chemical was determined in Cyprinus carpio . The BCF value was observed to be in range 44-161 L/kg at dose concentration 0.2 mg/L and 17-125 L/kg at dose concentration 0.02 mg/L on the basis of total lipid content on test organism Cyprinus carpio during 8 weeks period. Therefore it is concluded that this test chemical is nonbioaccumulative.These range BCF values indicate that the test chemical is not bioaccumulative in fish and food chain as these values are far less than 2000 criteria.
Additional information
Bioaccumulation: aquatic/sediments:
Various experimental studies and prediction have been reviewed for test chemical for bioaccumulation endpoint in water endpoint and their results are summarized below.
First study was experimental study reviewed from authoritative database ( J -check) in this study the bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) of chemical on test organism Cyprinus carpio. Nominal concentrations used in the study are Nominal concentrations 1st Concentration area: 0.2 ppm(v/v), 2nd Concentration area: 0.02 ppm(v/v) and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 16.8 ppm(w/v). The vehicle used in this study was HCO-40.The bioconcentration factor (BCF) for test chemical was determined in Cyprinus carpio . The BCF value was observed to be in range 44-161 L/kg at dose concentration 0.2 mg/L and 17-125 L/kg at dose concentration 0.02 mg/L on the basis of total lipid content on test organism Cyprinus carpio during 8 weeks period. Therefore it is concluded that this test chemical is nonbioaccumulative. These range BCF values indicate that the test chemical is non bioaccumulative in fish and food chain as these values are far less than 2000 criteria.
Another study was reviewed from Ecotoxicology and Environmental Safety journal (1980) in this study the BCF value of test chemical was estimated by using equation taken from Kenaga and Goring (1978). The bioaccumulation concentration factor of test chemical was estimated to be 16 dimensionless by using water solubility of test chemical. On the basis of BCF value it is concluded that test chemical is non bioaccumulative in nature.
In last study prediction was done by using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is 70.95 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical is non-bioaccumulative in food chain.
By considering results of all the studies mentioned above it is concluded that BCF value of test chemical is in range of 16-161 L/Kg this range BCF value indicates that test chemical is non bioaccumulative in nature.
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