Trifluoroacetic acid

Storage stability and reactivity towards container material

Administrative data

Endpoint:

storage stability and reactivity towards container material

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No data

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

ALLOY TESTING AND SELECTION FOR A NOVEL CHLOROSULFONIC ACID ENVIRONMENT

Author:

John Flahive, Don Korte and Bruce Nacker

Reference 2

Reference Type:

other company data

Title:

Unnamed

Materials and methods

Principles of method if other than guideline:

During the scale-up of a new active pharmaceutical ingredient (API), materials of construction issues were of high importance due to the extremely aggressive nature of the reaction mixture and the corrosive gases produced as transient species during the reaction. In the early stages of technology transfer of this process from R&D to manufacturing, existing materials of construction of critical plant equipment had to be evaluated for chemical compatibility.
To ensure compatibility, extensive lab corrosion testing was performed on various corrosion-resistant materials, including glass, nickel alloys, tantalum, zirconium, and titanium, for this challenging application. Due to the complexity of the reaction mixture, the literature survey was utilized as a starting point to
determine which materials might be good candidates for this extremely corrosive service. TFA results were found and are reported in the present summary.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

TFA

IUPAC Name:

TFA

Constituent 2

Reference substance name:

Trifluoroacetic acid

EC Number:

200-929-3

EC Name:

Trifluoroacetic acid

Cas Number:

76-05-1

Molecular formula:

C2HF3O2

IUPAC Name:

trifluoroacetic acid

Test material form:

not specified

Results and discussion

Results:

TFA with less than 0.1% water is not corrosive to aluminum, nickel, monel, steels and higher alloys (see below). It can also be handled in glass and plastics such as polyethylene, polypropylene, PTFE, PCTFE and others, but it reacts with oxygen-containing plastics. Typically, TFA is shipped in polyethylene carboys, lined drums or larger stainless steel containers.

Corrosion Rates for Various Metals in TFA:
- Nickel : 0.4 Mils/Year
- Monel(TM) : 0.7 Mils/Year
- SS304 : 1 Mils/Year
- SS316 : 0.07 Mils/Year
- Carpenter 20 : 0.06 Mils/Year
- Inconel(TM) : 0.4 Mils/Year
- Aluminium : 0.03 Mils/Year
- Copper : 5 Mils/Year

Source : The vendor, Halocarbon Products Corporation, supplied corrosion data on TFA

Applicant's summary and conclusion

Conclusions:

TFA with less than 0.1% water is not corrosive to aluminum, nickel, monel, steels and higher alloys.