Registration Dossier
Registration Dossier
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EC number: 471-110-8 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.1bis (Fest-Dosis-Methode)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test animals
- Species:
- other: rat, Sprague-Dawley ICO OFA.SD (IOPS Caw.)
Administration / exposure
- Vehicle:
- corn oil
- No. of animals per sex per dose:
- Preliminary sighting study: 2 (female)
Main study: 5 (male)
Main study: 5 (female) - Details on study design:
- Preliminary sighting study:
The test substance was administered at the doses of 500 and
50 mg/kg b.w. One female was used for each dose-level.
Main study:
The test substance was administered at the dose-level of
50 mg/kg b.w. to a group of 5 males and 5 females.
Results and discussion
- Preliminary study:
- Species/strain: rat, Sprague-Dawley ICO OFA.SD (IOPS Caw.)
500 mg/kg bw: Evident toxicity: Y; Mortality: Y
50 mg/kg bw: Evident toxicity: Y; Mortality: N
mg/kg bw: Evident toxicity: ; Mortality:
Observations:
50 and 500 mg/kg b.w.: Hypocactivity and piloerection.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 50 mg/kg bw
- Dose descriptor:
- other: 50 mg/kg bw (fixed dose initial)
- Remarks on result:
- other: No. with evident toxicity: 0; No. of deaths: 0; No. of animals used: 5
- Gross pathology:
- Effects on organs:
Macroscopic examination of the main organs of all animals
revealed no apparent abnormalities. - Other findings:
- No clinical signs and no mortality were observed at
50 mg/kg b.w.
Body weight gain of animals was not affected by treatment.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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