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EC number: 609-256-3 | CAS number: 365400-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
In a study following OECD 308 the test substance dissipated only moderately from the water in two water/sediment systems under aerobic conditions. The calculated DT50 values for the dissipation of the parent substance from the water phase were 38 and 327 days for the water-sandy loam and water-silty clay loam sediment systems, respectively (126.5 and 1088.8 days, recalculated to 12 °C). In the total test system, the calculated DT50 values were 69 and 578 days for the water-sandy loam and water-silty clay loam sediment systems, respectively (229.7 and 1924.5 days, recalculated to 12 °C). No major transformation products were detected in the water or sediment phases. The sole minor transformation product was 2-methylsulfonyl-4-(trifluorormethyl)benzoic acid which did not exceed 3% in the total system of either water-sediment system.
In the water-sandy loam sediment system,, <1% of the applied radioactivity was present as either CO2 or organic volatile compounds at the end of the study. In the water-silty clay loam sediment system, <0.1% of the applied radioactivity was present as either CO2 or organic volatile compounds at the end of the study.
The anaerobic biodegradation of test substance radiolabelled as [Pyrazole-3-14C] (M-250846-01-1) or [Phenyl-UL-14C]- (M-250839-01-2) (5-Hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)[2-(methylsulfonyl)-4-(trifluoromethyl)phenyl]-methanone was studied in identical pond water/sediment systems for 365 days in the dark at 20 ± 1 °C. For the [Pyrazole-3 -14C] labelled test substance the half-lives using first-order nonlinear degradation kinetics in anaerobic water and in the entire system were 75 days (k = 0.0093 day-1; r² = 0.56) and 227 days (k = 0.0031 day-1; r² = 0.46), respectively (159.2 and 481.9 days, recalculated to 12 °C). For the [Phenyl-UL-14C] labelled test substance, the half-lives using first-order nonlinear degradation kinetics in anaerobic water and in the entire system equalled 84 days (k= 0.0083 day-1; r² = 0.63) and 273 days (k = 0.0025 day-1; r² = 0.40), respectively (178.3 and 579.6 days, recalculated to 12 °C). No major transformation products were detected in the water or sediment phases of either test system. There was no degradation of test substance in either anaerobic test system, but test substance partitioned to the sediment and formed bound residues. At the end of the study, 1.8 and 2.8% of the applied radioactivity was present as CO2, respectively.
In soil, the biodegradation of radiolabelled test substance in a silty clay loam at 20 °C under aerobic conditions (M-765810-01-1), conducted according to OECD Guideline 307 (2002) and GLP, was faster. After an incubation period of 119 days 22.6% of the applied radioactivity were mineralized to 14CO2. The degradation half-life of the parent substance was calculated using a first order multi compartment model (FOMC) and accounted for 3.06 days (6.5 days, recalculated to 12 °C).
Investigations on the aerobic/anaerobic biotransformation of radiolabelled test substance, according to OECD 307, revealed degradation half-lives of >120 days for the parent substance.
At the end of the aerobic phase 1.3% and 1.4% of the applied radioactivity was present as CO2
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