(2S)-5-amino-2-[(aminoacetyl)amino]-5-oxopentanoic acid

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 Dec 2021 - 10 Mar 2022

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

July 23, 2009

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

March 23, 2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Key result

Temp.:

20 °C

Vapour pressure:

< 0 Pa

Temp.:

25 °C

Vapour pressure:

< 0 Pa

Conclusions:

The vapour pressure of the test item was determined to be <8.4 e-7 Pa at 20 °C and < 6.2e-7 at 25 °C

Reference 2

Endpoint:

vapour pressure

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

1. SOFTWARE
EPI Suite v4.11 Estimation Programs Interface Suite™ for Microsoft® Windows v 4.11. US EPA, United States Environmental Protection Agency, Washington, DC, USA.

2. MODEL (incl. version number)
Mpbpwin v. 1.43

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
O=C(N)CCC(C(=O)(O))NC(=O)(CN)

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See information on the model in “Attached justification”.

5. APPLICABILITY DOMAIN
See information on the model in “Attached justification” and information provided in "Overall remarks, attachments" section.

6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section.

Qualifier:

according to guideline

Guideline:

other: REACH Guidance on QSARs R.6

Principles of method if other than guideline:

- Software tool(s) used including version: EPI Suite v4.11
- Model(s) used: Mpbpwin v1.43
- Model description: see information on the model in “Attached justification”.
- Justification of QSAR prediction: see field “Justification for type of information” and “overall remarks”.

GLP compliance:

no

Type of method:

other: QSAR

Key result

Temp.:

25 °C

Vapour pressure:

< 0 Pa

Remarks on result:

other: key value selected for the chemical safety assessment (see "Overall remarks")

Temp.:

25 °C

Vapour pressure:

0 Pa

Remarks on result:

other: Vapour presure calculated by the model (Modified Grain Method)

Conclusions:

A vapour pressure < 0.00001 Pa at 25 °C has been estimated based on a calculated value of 2.03E-8 Pa ((Q)SAR model: EPI Suite MPBPWIN v1.43)

Description of key information

Vapour pressure: < 8.4e-7 Pa at 20 °C (OECD 104, GLP)

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

20 °C

Additional information

According to OECD Test Guideline 104 (2006) and Regulation (EC) No 440/2008 Method A.4., the Vapour pressure of the test item Glycyl-L-glutamine monohydrate / (Gly-Gln) at 20 °C is:
<8.4e-7 Pa.