trans-(5RS,6SR)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol

Explosiveness

Administrative data

Endpoint:

explosiveness, other

Type of information:

other: Expert statemente

Adequacy of study:

other information

Justification for type of information:

The test methods in EEC A.14 of the EC Test Guideline are used to determine whether substances or preparations present an explosion hazard when ignited by flame (thermal sensitivity) or when subjected to shock or friction (mechanical sensitivity). The tests are superfluous if thermodynamic data are known that indicate beyond any doubt that the substance cannot decompose with rapid, heat-generating formation of gases (i.e., the substance does not present an explosion hazard).
From the temperature-programmed DTA measurements with a heating rate of 5 K/min, two exothermic decompositions can be identified for the test substance, whose decomposition enthalpies of -94.1 J/g and -233.1 J/g can be classified as low and which indicate from the slope of the heat flow curves that they are not spontaneous or very rapid decompositions.
As can be seen from the structural formula, the test substance does not have any reactive groups that store energy that could be released in the form of heat during decomposition. The oxygen balance for the test substance also shows that it is not an oxidant. That is, the test substance does not exhibit the property of exploding into complete combustion products. The oxygen balance of a substance CiHjNkOn is given by:

- 1600 -(2i + 1/2 - n) / molecular weight

and represents an index of the available oxygen in the molecule itself when 100 g of the substance explode to complete combustion products.

C7H15NO3 + 18.5 O ===> 7 C02 + 7.5 H2O + 0.5 N2

For the test substance, the oxygen balance is -183.6 g/ 100 g, i.e. the oxygen content of the test substance is not sufficient for complete combustion.
In the tests carried out for spontaneous ignition, flammability and combustibility, no evidence was obtained of rapid, heat-supplying decomposition with the formation of gases.
For these reasons, testing according to A 14 of the EC Directive for explosion hazard is not required for the test substance.

Ref. 1: Brethericks's Handbook of Reactive Chemical Hazards, 4th. Edition, Butterworth & Co. (Publishers) Ltd, 1990.
Ref. 2: P.F. Nolan, "Evaluation of Chemical Reaction Hazards" in Hazards X, Process Safety in Fine and Speciallity Chemical Plants, p 45, EFCE Publication No 75, 1989.
Ref. 3: T. Yoshida, "Safety of Reactive Chemicals", Industrial Safety Series Volume 1, Elsevier, 1987.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993