Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 February 2021 to 22 March 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- A modified flask method was used due to the very high saturation level
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- A modified flask method was used due to the very high saturation level
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Remarks:
- modified
- Key result
- Water solubility:
- >= 50 other: % w/w
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 0.2
- Conclusions:
- The water solubility of the test item has been determined to be greater than 50.0% w/w of solution at 20.0 ± 0.5 °C.
- Executive summary:
The water solubility of the test item has been determined to be greater than 50.0% w/w of solution at 20.0 ± 0.5 °C, using a modified flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No. 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The modified flask method was necessary due to the very high saturation level of the test item.
Reference
The sample concentrations and observations after standing are shown in the following table:
Table 2
Sample | Concentration (% w/w) | Solution pH | Observations |
1 | 5.08 | 1.3 | Clear, colourless, non-viscous solution |
2 | 25.1 | 0.9 | Clear, light pink, non-viscous solution |
3 | 50.0 | 0.2 | Clear, pink, non-viscous solution |
Description of key information
≥ 50% w/w of solution at 20°C, pH 0.2; Walker, J.A., (2021)
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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